Hiccup Hell

BamaCrazy

Banned
I will preface this write up by saying it’s not meant to criticize the source nor GLPs.

On 4/4 I injected 10mg of Reta that I had received a few days earlier from GYC. They had just had a GB for Reta 50 for a great price. Up until 4/4 I had been injecting 8mg a week for the previous 6 months. But to make things easy I upped it to 10 to get 5 weeks per vial.

On 4/5 during breakfast (24 hours later) I noticed that I was full halfway through my meal of yogurt and berries. I couldn’t finish my meal which was unusual for me. On Reta I can usually eat as much or as little as I want. Soon after breakfast I started having hiccups. Which only got worse as the day went along. They were happening so often that I was not able to hold my dinner down. I was only able to sleep that night with the help of gabapentin which I read about online.

This continued in the days after so I quit eating after lunch. After the first week it was only getting worse. There were times when my diaphragm was spasming in such succession that it was cutting off my air supply. I was just not able to breathe in if they caught me after breathing out. So I scheduled a doctor’s appointment which led to chest x-rays, bloodwork, three changes to medication, a visit to the ER (what a total waste of time), an EKG, a Neurology appointment and a Gastroenterologist appointment. The Gastroenterologist scheduled a CT scan of my abdomen and chest, and an Endoscopy (EGD). The Neurologist scheduled an MRI of my brain to look for lesions. By now I’m around day 20 with nonstop hiccups. I’ve missed 2 weeks of work. I can barely eat, sleep, breathe or talk without issues. Most days mornings were ok, but after lunch things took a turn for the worse.

On day 20 the hiccups were better and I only had 3 hours of hiccups. On day 21 I had my EGD. He did find a hiatal hernia during the procedure but said it was too small to be causing my issues. He blamed GLPs. They all think I’m using the Sema I’ve been prescribed which I’ve never used once. They know nothing of the Reta. GLPs affect the vagus nerve which controls the movement of the diaphragm. He says once the drug is out of my system things will get better. He thought I had just quit using the Sema but I told them during intake that I quit 3 weeks prior. He said it could take weeks to exit my system.

The day of the procedure I had no hiccups. I have had no hiccups since. And before you ask, yes, I tried everything. Vinegar, lemons, spoon fulls of dry sugar, holding my breath, breathing in a bag, drinking from a glass from the wrong side, pulling my tongue, pulling my legs into my stomach, drinking water nonstop, valsalva maneuver, squeezing my nose, etc. Nothing helped.

When this all began I suspected the Reta so I joined a testing group and donated one of my vials which was sent to Jano with a 2nd vial from another participant. The results returned today. One vial tested at 57.88mg and the other 58.24. So taking an average of 58mg I calculate I injected 11.6mg that day which was a big jump from 8mg. I guess big enough to anger my vagus nerve. Needless to say I am done with GLPs. I’m not even going to chance it.

Something so simple as a hiccup turned my world completely upside down. It was a wild 3 weeks and I cannot believe it finally ended. There are people who get hiccups for years and I’m not sure how they keep going. I consider myself a strong person but I just couldn’t live like that.

If you made it this far thanks for sticking with me and reading until the end. Lol
 

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That's intense ....like fucking "missed 2 weeks of work" bad hiccups. Glad you found an underlying cause.

I'm pretty sure you use GLPs just to make cuts easier etc. (as opposed to for obesity) but I don't keep track of the whole crowd.

I don't see why you couldn't start back at a low dose....or at least look at the data (if any has been released) on hiccups and Retatrutide...as well as average dose that caused, how long to resolve etc.

I get why you would have no desire to resume at any dose especially when the memory is so fresh.

P.S. the rare times I have been comprehensively and appropriately worked up for a health problem, I always embrace the NEGATIVE data (i.e. the tests that didn't find anything wrong with you). That might make the experience a tiny bit more worthwhile.

Also "small hiatal hernia".... theory on why? Due to lifting? Genetics? Cough your brains out for a year? Not sure I know enough about the underlying pathology in humans but probably worth monitoring for signs as you age. (#unsolicited advice)
 
I get hiccups from tirz sometimes if I eat too much. It sucks. Pro tip, if you have some zanaflex on hand, 2 of those (double recommended dose) seem to knock out the worst cases for me.

I haven't had them in a while. I'm careful what I eat at night and that keeps them at bay.
 
That's intense ....like fucking "missed 2 weeks of work" bad hiccups. Glad you found an underlying cause.

I'm pretty sure you use GLPs just to make cuts easier etc. (as opposed to for obesity) but I don't keep track of the whole crowd.

I don't see why you couldn't start back at a low dose....or at least look at the data (if any has been released) on hiccups and Retatrutide...as well as average dose that caused, how long to resolve etc.

I get why you would have no desire to resume at any dose especially when the memory is so fresh.

P.S. the rare times I have been comprehensively and appropriately worked up for a health problem, I always embrace the NEGATIVE data (i.e. the tests that didn't find anything wrong with you). That might make the experience a tiny bit more worthwhile.

Also "small hiatal hernia".... theory on why? Due to lifting? Genetics? Cough your brains out for a year? Not sure I know enough about the underlying pathology in humans but probably worth monitoring for signs as you age. (#unsolicited advice)
The primary causes of hiatal hernias are age related changes to the body. More common after 50. I’m 54. Obesity. Which I am not. And forceful coughing, sneezing or heavy lifting. My guess is age mixed with heavy lifting. Some people have no symptoms. Some people get acid reflux or Gerd. The doc said mine was too small for my esophagus or stomach to slide up through the hernia. And I have no other symptoms. So it’ll just be something I keep an eye on.
 
I wasn’t aware. If you know ahead of time I guess that can be a good thing.
Quite alot of vendors overfill..but not to such an extend.

For e.g, Q always overfills the hgh, I dont recall if its 34 or 36 iu but I've always treated it as 40. Some people complain that they always end up holding water..well duh it's overfilled..you're pinning more than the other vendor you're comparing with..
 
Dam brother what a hell of a ride. Glad your OK. The experimenter in me wants you to try a 5mg dose and see what happens. Or better yet, have a buddy you know who is on Reta give it a try to see if its a one off or a bad batch of Reta some how.
 
I get hiccups from tirz sometimes if I eat too much. It sucks. Pro tip, if you have some zanaflex on hand, 2 of those (double recommended dose) seem to knock out the worst cases for me.

I haven't had them in a while. I'm careful what I eat at night and that keeps them at bay.
That’s interesting. It’s like a muscle relaxer and a nerve blocker. One of the drug pairs they gave me was baclofen and gabapentin which is a muscle relaxer and a nerve blocker. I’ll have to grab some from one of the PCT sources. PCT Zone calls it Trinex.
 
Dam brother what a hell of a ride. Glad your OK. The experimenter in me wants you to try a 5mg dose and see what happens. Or better yet, have a buddy you know who is on Reta give it a try to see if it’s a one off or a bad batch of Reta some how.
I know someone who already takes high dose Reta and bought the same Reta 50. Maybe I can convince him to try his out.

I would try low dose but I just wasted 2 weeks of PTO. I’d like to burn the rest on an actual vacation. lol
 
I'm on 15mg Reta now...honestly don't get any appetite suppression from Reta which is great. I did not experience any hiccups after accidentally pinning a whole 30mg vial last week..:rolleyes:

One of the drug pairs they gave me was baclofen and gabapentin which is a muscle relaxer and a nerve blocker.

Did it help?
 
I'm on 15mg Reta now...honestly don't get any appetite suppression from Reta which is great. I did not experience any hiccups after accidentally pinning a whole 30mg vial last week..:rolleyes:



Did it help?
Nothing helped. They tried Pantoprazole, baclofen, gabapentin, chlorpromazine, metoclopramide and Omeprazole. Most of those muscle relaxers and nerve blockers just made me sleepy. Sleepy with hiccups.
 
I'm on 15mg Reta now...honestly don't get any appetite suppression from Reta which is great. I did not experience any hiccups after accidentally pinning a whole 30mg vial last week..:rolleyes:



Did it help?
I had the same problem with Sema, no appetite suppression even at 2.5mg/week. I got an actual prescription for Wegovy but had to start at 0.25mg/week. After 5 weeks I was starving all the time (so I guess it was doing something). I supplemented the 0.5mg/week dose and brought it back up to 2.5mg/week and BAM, the shit finally worked like everyone said it did. I could barely finish 100g rice and 170g chicken without feeling stuffed. The good news is I'm on a cut, and can barely get 1500 calories down a day. I'm loosing a little over 2lbs a week and will get down to my target 10% body fat (starting at 17%) in no time.
 
There's much more going on in regards to potency and half life than peptide purity tests indicate.

It sounds like you got an exceptionally strong batch compared to what you had previously. Or maybe just fucked up in a way that caused stronger receptor binding to something inducing hiccups.

I had a conversation with a pharmaceutical scientist, and he was able to connect me with a lab that had a look at a leftover vial of QSC 30mg group buy Tirz that had tested at around 98% purity, yet 20mg doses I had been taking for months (which did work) were clearly not as strong as 15mg pharma.

Despite the dismissal of "feels", it became obvious after going back to 15mg pharma pens. While I was expecting a lessening of effect, it was so strong I ate too much for the dose, and ended up getting severe sides. The duration of appetite suppression was clearly longer than the QSC Tirz as well.

TLDR, I had a battery of tests done on that vial, which, despite a huge discount still cost $1400.

HPLC-MS showed this year old vial at ~96%+ "purity", but an NMR analysis, which I never heard of before, revealed two major problems.

One was that an expensive, hard to get ingredient in Tirz was substituted in the QSC Tirz for a cheap cosmetic ingredient, and the second was a "lipid linker" attached to the wrong part of the peptide. Doing it this way likely cut the time to manufacture the Tirz in half.

Neither is these is detectable by an HPLC-MS "purity" analysis, and among other (some potentially health harming) issues, can reduce potency and duration.

This might explain why batches of GLPs, rHGH, and other peptides can seemingly vary so much in potency despite appearing in HPLC-MS to have similar purity and dosing.
 
There's much more going on in regards to potency and half life than peptide purity tests indicate.

It sounds like you got an exceptionally strong batch compared to what you had previously. Or maybe just fucked up in a way that caused stronger receptor binding to something inducing hiccups.

I had a conversation with a pharmaceutical scientist, and he was able to connect me with a lab that had a look at a leftover vial of QSC 30mg group buy Tirz that had tested at around 98% purity, yet 20mg doses I had been taking for months (which did work) were clearly not as strong as 15mg pharma.

Despite the dismissal of "feels", it became obvious after going back to 15mg pharma pens. While I was expecting a lessening of effect, it was so strong I ate too much for the dose, and ended up getting severe sides. The duration of appetite suppression was clearly longer than the QSC Tirz as well.

TLDR, I had a battery of tests done on that vial, which, despite a huge discount still cost $1400.

HPLC-MS showed this year old vial at ~96%+ "purity", but an NMR analysis, which I never heard of before, revealed two major problems.

One was that an expensive, hard to get ingredient in Tirz was substituted in the QSC Tirz for a cheap cosmetic ingredient, and the second was a "lipid linker" attached to the wrong part of the peptide. Doing it this way likely cut the time to manufacture the Tirz in half.

Neither is these is detectable by an HPLC-MS "purity" analysis, and among other (some potentially health harming) issues, can reduce potency and duration.

This might explain why batches of GLPs, rHGH, and other peptides can seemingly vary so much in potency despite appearing in HPLC-MS to have similar purity and dosing.
Can you posts all of the tests/data? What does Jano think?
 
There's much more going on in regards to potency and half life than peptide purity tests indicate.

It sounds like you got an exceptionally strong batch compared to what you had previously. Or maybe just fucked up in a way that caused stronger receptor binding to something inducing hiccups.

I had a conversation with a pharmaceutical scientist, and he was able to connect me with a lab that had a look at a leftover vial of QSC 30mg group buy Tirz that had tested at around 98% purity, yet 20mg doses I had been taking for months (which did work) were clearly not as strong as 15mg pharma.

Despite the dismissal of "feels", it became obvious after going back to 15mg pharma pens. While I was expecting a lessening of effect, it was so strong I ate too much for the dose, and ended up getting severe sides. The duration of appetite suppression was clearly longer than the QSC Tirz as well.

TLDR, I had a battery of tests done on that vial, which, despite a huge discount still cost $1400.

HPLC-MS showed this year old vial at ~96%+ "purity", but an NMR analysis, which I never heard of before, revealed two major problems.

One was that an expensive, hard to get ingredient in Tirz was substituted in the QSC Tirz for a cheap cosmetic ingredient, and the second was a "lipid linker" attached to the wrong part of the peptide. Doing it this way likely cut the time to manufacture the Tirz in half.

Neither is these is detectable by an HPLC-MS "purity" analysis, and among other (some potentially health harming) issues, can reduce potency and duration.

This might explain why batches of GLPs, rHGH, and other peptides can seemingly vary so much in potency despite appearing in HPLC-MS to have similar purity and dosing.

Jano also does NMR..not sure about cost tho.
UGL costs alot lesser than Pharma..naturally you can except the same ingredients..
 
Can you posts all of the tests/data? What does Jano think?

This is a legit testing facility used by compounding pharmacies and other commercial entities. It's not exactly "UGL friendly", and not set up to provide anonymity, cannot accept controlled substances without a DEA license (no sending in rHGH), or frankly, even work with individuals. I got this in through someone else's commercial account and don't want to compromise them. The "retail" for all the tests would have been over $4000.

That said, given its significance, I've asked my connection for permission to post a redacted version of the NMR portion of the analysis, which is all that mattered in this case. So perhaps I'll make a separate post on this shortly.

I'll also add that NMR testing services are available from a number of labs for under $500. We were starting from scratch so 4 different tests were conducted, but as it turned out, all the "dirty secrets" regarding the shortcuts taken to make this Tirz were in the NMR.

I'll update here when I post it,
 
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Jano also does NMR..not sure about cost tho.
UGL costs alot lesser than Pharma..naturally you can except the same ingredients..

Yeah but this ingredient is very important, at the least for duration.

"Expected: C20 fatty diacid linker with PEG spacer.
Observed: C16 saturated fatty acid (palmitic acid) with a shorter PEG linker.
Evidence: Absence of diagnostic methylene signals for C20; PEG integration for only 3 units."

"Clinical Significance
- Shorter C16 chain may weaken albumin binding, reducing half-life and affecting dosing "

In a follow up, I was told this substitution would also likely affect other properties of the Tirz besides reduce half life. It could even induce immune reactions, but that would require an Enzyme-Linked Immunosorbent Assay for another $10,000+ lol.
 
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