Sigma Audley Inc. - Your source for peptides, ancillaries, AAS, and more!

SSA TNE smells like it's just 100% pure guaiacol. You literally start breathing it out moments after injecting. Not great
I had a similar experience with Mast E from Q. I believe there is some solvent besides BB. Only used a part of one bottle chucked the rest out. Instant headache after pinning and could taste it. Strong smell from vial after pinning. They claim they didn't use anything but BB, but not sure on that one.
 
I had a similar experience with Mast E from Q. I believe there is some solvent besides BB. Only used a part of one bottle chucked the rest out. Instant headache after pinning and could taste it. Strong smell from vial after pinning. They claim they didn't use anything but BB, but not sure on that one.
Could be EO, I know a few Chinese vendors who use that in their mast.
 
Last edited:
I added Dimer testing to my order. I think all HGH has some level of dimer. Just a matter of what's considered OK?! @Ghoul would know more.

Dimer is essentially the smallest type of aggregate. Two monomers attached to each other.

The largest aggregates can be comprised of tens of thousands of monomers.

rHGH dimer isn't a major concern as it doesn't present a health risk. It's just less bioactive than monomer, so there's a weaker response.

The UGL community became fixated on it a few years ago, though the vast majority couldn't tell you what it is or why it matters.

UGL manufacturers responded to this by including a filtration step to remove it,

Large aggregates, unlike dimer, are not active as rHGH and DO present health risks, form as a result of instability of the formulation and poor handling, and as we've discussed, these contaminants are filtered out before analysis and are not measured at all. The rHGH could contain a massive amount of large aggregates, which would be completely unacceptable in a regulated pharmaceutical (and often results in the failure of new peptide drugs to get approval), and still come back as 99% pure even if it's only 70% pure had the aggregates been included.

I keep repeating this analogy so it'll sink in:

It's like testing your drinking water for safety and purity after filtering it, then based on the good result, drinking straight from the tap.

If you want to inject the purity level you see in the analysis, you need to filter the same way (.22um PES) it's filtered prior to being analyzed.
 
Last edited:
Dimer is essentially the smallest type of aggregate. Two monomers attached to each other.

The largest aggregates can be comprised of tens of thousands of monomers.

rHGH dimer isn't a major concern as it doesn't present a health risk. It's just less bioactive than monomer, so there's a weaker response.

The UGL community became fixated on it a few years ago, though the vast majority couldn't tell you what it is or why it matters.

UGL manufacturers responded to this by including a filtration step to remove it,

Large aggregates, unlike dimer, are not active as rHGH and DO present health risks, form as a result of instability of the formulation and poor handling, and as we've discussed, these contaminants are filtered out before analysis and are not measured at all. The rHGH could contain a massive amount of large aggregates, which would be completely unacceptable in a regulated pharmaceutical (and often results in the failure of new peptide drugs to get approval), and still come back as 99% pure even if it's only 70% pure had the aggregates been included.

I keep repeating this analogy so it'll sink in:

It's like testing your drinking water for safety and purity after filtering it, then based on the good result, drinking straight from the tap.

If you want to inject the purity level you see in the analysis, you need to filter the same way (.22um PES) it's filtered prior to being analyzed.
That's very interesting.

Do you mean Janoshik filters prior to performing HPLC?
 
Back
Top