SLU-PP-332 – an Exercise Mimetic for Metabolic Health and Performance Enhancement
SLU-PP-332 is a synthetic estrogen receptor-related orphan receptor (ERR) agonist that mimics the health benefits of exercise. It activates ERRs, which play a crucial role in regulating metabolic processes in high-energy-demand tissues such as skeletal muscle, the heart, brain, liver, and fat tissue. This compound has shown promising effects in enhancing metabolism, improving physical performance, and potentially treating various metabolic disorders.
How does SLU-PP-332 work?

ERR Activation – SLU-PP-332 acts as a non-selective agonist for ERRα, ERRβ, and ERRγ, with EC50 values of 98 nM, 230 nM, and 430 nM, respectively. This activation leads to increased energy expenditure and fatty acid oxidation.

Metabolic Enhancement – It boosts mitochondrial function and cellular respiration, similar to the effects of exercise. This results in improved fat metabolism and overall metabolic efficiency.

Muscle Fiber Composition – SLU-PP-332 increases type IIa oxidative skeletal muscle fibers, enhancing muscle endurance and performance.

Exercise Mimetic – It activates genes that are typically only activated by acute aerobic exercise, even in sedentary individuals. This means it can provide exercise-like benefits without the need for physical activity.
Who is it for?
Individuals with physical limitations – those who cannot engage in traditional exercise due to health conditions or other constraints.
Athletes and fitness enthusiasts – to enhance performance, endurance, and recovery.
People with metabolic disorders – such as obesity, type 2 diabetes, and metabolic syndrome.
Those looking to improve overall health and fitness – without relying solely on extensive workouts.
How to use?
SLU-PP-332 is still in preclinical stages, and there are no established usage guidelines for humans. However, research in mouse models has shown promising results, with administration twice daily for a month leading to significant improvements in body composition and exercise endurance. Improved versions are being developed for potential future clinical trials.
Conclusion:
SLU-PP-332 is a groundbreaking compound that offers a novel approach to enhancing physical health and performance by mimicking the effects of exercise. When used correctly and with further research, it has the potential to revolutionize fitness strategies, support weight management, and improve metabolic health.