MESO-Rx
Anabolic Steroids
low COMT function
- Thread starter Amgiji
- Start date
AlexDavis43
Member
Depending on what service you had that assessed, they have a recommendation section. Probably have to pay for it.
There are also some other people/services who will analyze your results and provide recs, but you have to pay for them too. LifeDNA, MasterPass, and a few others, etc.
Kralteramon
Member
I have the same mutation "worrier". Also wondering the same. There barely is any information out there. However I did find that homovanilic acid plays a crucial role in the breakdown of dopamine and worrier met/met type carriers have less of it. I'm currently experimenting with low dose Nandrolone (150mg wk) as Nand increases homovanilic acid and enhances the dopamine breakdown mechanism resulting in more motivation and cognitive enhancement. However chronic and or high dose nand actually downregulates dopamine receptors and is directly toxic to the dopamine system so it's not just a boon. I'm not advocating for using nand at all but it might help as I'm also trying to find out how to deal with the downsides of the SNP. It truly has a lot of downsides.. upside is good memory and recall. There are a few more but for me it's mostly downsides.. ADHD symptoms, anxiety etc. I believe it all comes from the cathecholamine alterations that this gene emposes. Would love to have a bigger discussion around this topic!
Kralteramon
Member
I wanted to add. COMT uses methylation to break down dopamine into homovanilic acid so anything that supports methylation or acts as a methyl donar can help too. I'm using TMG for this.
Very large doses of magnesium will help, aswell as high doses of methylated b vitamins, especially riboflavin, methylcobalamine and P5P. Folate should be methylated aswell and low dosed compared to other b vitamins.
Creatine will play a very important part but im sure you take it already.
TMG(500mg-1g) is a great addition to a diet with plenty choline in it (eggs are a great source)
When that is in your daily routine you can dabble with SAM-e, get coated 200mg tablets and take em on empty stomach in the morning, start with not even one a day or you may get overmethylated.
Do this process slowly.
Agmatine sulfate may be good if you have cathecolamine overload
Creatine will play a very important part but im sure you take it already.
TMG(500mg-1g) is a great addition to a diet with plenty choline in it (eggs are a great source)
When that is in your daily routine you can dabble with SAM-e, get coated 200mg tablets and take em on empty stomach in the morning, start with not even one a day or you may get overmethylated.
Do this process slowly.
Agmatine sulfate may be good if you have cathecolamine overload
thank you for the information, I will look into Agmatine sulfate.
as a side question do you know why someone who is mthfr c677t homozygous for the non functional one would always have high b6/p5p
even when not taking any?
eery
Member
I believe dr dean st mart has done some content on this, check out his instagram and his content on youtube.
Not sure, didnt know this was a thing. Some lacking cofactor maybe making p5p metabolism dysfunctional? I'm pretty sure people with this variant tend to have low magnesium and zinc so that could be why.
I'm heterozygous C677T and Val158Met COMT and I do very high magnesium with good result (600mg-1g). Pretty sure if you're homozygous you can go ham with the thing I mentioned with good result.
Are you homozygous for COMT aswell?
I'm also Val158Met COMT.
I had a cortisol test come back a such a high amount that the endocrinologist gave me an mri looking for a pheochromocytoma, but there was none.
the cortisol blocker they gave me for the test worked but they are difficult to get and cause a buildup of mineralocorticoids.
and the only things I can find that upregulate MOA-A are psychiatric medication with an "unacceptable risk profile"
so, I am left trying to increase COMT function however I reasonably can to lower catecholamines.
Sounds rough buddy. Whats your stack for COMT currently? Are you avoiding stims? I do the entire routine i mentioned minus agmatine which im soon to try. Im down to one cup of coffee per day with plenty coconut oil. Heavy dose of NAC so I can train without getting sick from oxidative stress and do my 4-5x weekly sauna and cold showers to clear catecholamines. Phenibut when im overcharged. Extra aromasin when im overcharged since estrogen doesnt get cleared as good.
no caffeine.
I'm not sure what ones are relevant so here's the full list of what I take each day for supplements is :
sam-e 400mg.
nac 600mg.
R-alpha lipoic acid 1,200mg.
sodium 60mg.
magnesium glycinate 120mg only 6 days a week or it goes over the reference range of 2.6mg/dl.
creapure creatine 5G.
reacted cal mag: calcium 442 mg phosphorus 112 mg magnesium 350 mg split into 2 times a day.
taurine (free form) 500 mg.
biotin 30 mcg.
akg 1,000 mg.
calcium pyruvate 8,000 mg split into two times a day.
retinyl palmitate1,500 mcg
tmg 500 mg.
glucosamine hci1,600mg/chondroitin sulfate 1,200 mg
digestive enzymes 391 mg including protease 60,000 hut, glucoamylase 30 agu, lipase3,000 fip.
my zinc is high so, copper glycinate 8mg split into 2 times a day.
cholecalciferol(d3) 125mcg or 5,000 iu only 6 days a week or it goes over the reference range of 80 ng/ml.
manaquinone-7 100 mcg.
msm 3,400 mg
manganese 50% aspartate 50% citrate 8mg.
potassium iodide 225 mcg only twice a week or it nukes my tsh.
L-ascorbic acid 1,012 mg.
menatertrenone-4 15,000 mcg
probiotics 1,800mg mostly being varieties of lactobacillus.
vitamin E as d-alpha tocopherol 134 mg/ tocotrienols d-alpha, d-beta, d-gamma d-delta 50mg/ tocopherols d-alpha, d-beta, d-gamma, d-delta 25mg.
Ribose 5-phosphate 2mg.
d- panthenol 5mg.
1ml of a sublingual drop consisting of methylcobalamin0.2mg/ml,
5-methyltetrahydrofolate 5mg/ml, thiamine pyrophosphate3mg/ml,
nicotinic acid 15mg/ml
I'm not sure what ones are relevant so here's the full list of what I take each day for supplements is :
sam-e 400mg.
nac 600mg.
R-alpha lipoic acid 1,200mg.
sodium 60mg.
magnesium glycinate 120mg only 6 days a week or it goes over the reference range of 2.6mg/dl.
creapure creatine 5G.
reacted cal mag: calcium 442 mg phosphorus 112 mg magnesium 350 mg split into 2 times a day.
taurine (free form) 500 mg.
biotin 30 mcg.
akg 1,000 mg.
calcium pyruvate 8,000 mg split into two times a day.
retinyl palmitate1,500 mcg
tmg 500 mg.
glucosamine hci1,600mg/chondroitin sulfate 1,200 mg
digestive enzymes 391 mg including protease 60,000 hut, glucoamylase 30 agu, lipase3,000 fip.
my zinc is high so, copper glycinate 8mg split into 2 times a day.
cholecalciferol(d3) 125mcg or 5,000 iu only 6 days a week or it goes over the reference range of 80 ng/ml.
manaquinone-7 100 mcg.
msm 3,400 mg
manganese 50% aspartate 50% citrate 8mg.
potassium iodide 225 mcg only twice a week or it nukes my tsh.
L-ascorbic acid 1,012 mg.
menatertrenone-4 15,000 mcg
probiotics 1,800mg mostly being varieties of lactobacillus.
vitamin E as d-alpha tocopherol 134 mg/ tocotrienols d-alpha, d-beta, d-gamma d-delta 50mg/ tocopherols d-alpha, d-beta, d-gamma, d-delta 25mg.
Ribose 5-phosphate 2mg.
d- panthenol 5mg.
1ml of a sublingual drop consisting of methylcobalamin0.2mg/ml,
5-methyltetrahydrofolate 5mg/ml, thiamine pyrophosphate3mg/ml,
nicotinic acid 15mg/ml
forgot the omega
ahiflower 80dha (buglossoides arvensis) seed with schizochytrium spp 500 mg.
elantria algae oil (from schizochytrium sp) 1,000 mg.
omega 3 960 mg comprised of
dha 480 mg.
epa 226 mg.
ala 166 mg.
sda 70 mg.
omega 6 62 mg comprised of
gla 18 mg.
LA 44 mg.
omega 9 24 mg comprised of
oa 24 mg
ahiflower 80dha (buglossoides arvensis) seed with schizochytrium spp 500 mg.
elantria algae oil (from schizochytrium sp) 1,000 mg.
omega 3 960 mg comprised of
dha 480 mg.
epa 226 mg.
ala 166 mg.
sda 70 mg.
omega 6 62 mg comprised of
gla 18 mg.
LA 44 mg.
omega 9 24 mg comprised of
oa 24 mg
I know it's a lot I have a lot of health problems some related some not, but
other than the Agmatine sulfate is there anything else specially for the low comt/cathecolamine overload?
nullandvoid
Member
Chasing methylation/mutations is a dead-end. This has been hyped for years for the sake of selling supplements, convincing people they need yet another compound for their bodies to function. It also gives people something to blame other than their poor lifestyle choices. The body adapts... and has adapted. There are multiple pathways and processes. That supplement list is a red flag. I've been there, and I've done it. That's how I know. Is it useful to tweak some things once you have other things in check? Sure. It's also useful to know what to avoid.. like in my case I avoid methyl/cyano forms of B12. They make me irritable as hell, and now I know why. But overwhelmingly, I guarantee your problems aren't mutations. They are the one place you and the majority of everyone else don't want to look or take accountability: diet.
my diet is why I take a laundry list of supplements.
I can only tolerate plain meat and non-iodized salt.
everything I ate made my lips, eyes and gums itch, red irritated tongue, endless thirst, made me feel hot and agitated and then brain fog and tired like I chugged Benadryl.
I went to an allergist he did 8-12 sets of scratch tests I had over 30 marks, the only things that came back fine was pork, chicken and beef.
so, for me every meal is chuck roast cut up, boiled in tap water in a stainless-steel pot or 80/20 ground beef fried in a frying pan with the only thing added being non-iodizes salt. that's it.
I feel better now that I've been doing that, but it comes with a lot of risks.
that's why I take so much, I try to take some of everything I reasonably can, so I don't end up with a nutrient deficiency no one has seen is 80 years.
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