You mean when it was originally released?
It's been available as a solo medication for quite some time, or in any number of double and triple combos.
I want this one:
View attachment 318370
Cilnidipine is currently in clinical trials combined with Tadalifil for treatment of Reynauds, a condition where cold makes small blood vessels spasm, often resulting in painful toes or fingers, which is funny, since I realized I had this widespread but largely undiagnosed (20% of adults) condition, and it seemed to be fixed once I started using amlodipine and daily tadalifil regularly.
More than 27 million Americans suffer from Raynaud’s and yet no drug is specifically approved for the treatment of Raynaud’s disease in the United States.
aisapharma.com