Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[anon55]

The thing is, it's not as if the only way to achieve what he's trying is via micro dosing. The people using it this way think they're improving something with no additional risk. They're simply unaware of immunogenicity and its consequences.

Imagine discovering you slowly built a cross immunity to your natural GLP-1, a crucial endogenous peptide.

Such things have happened with pharma peptides, catastrophes, and took years and years to develop.

A really known case for this is metreleptin use for lipodystrophy. After a long time, most of the patients develop antibodies against the drug and a lot of them against their natural leptin.

 

[Ghoul]

A really known case for this is metreleptin use for lipodystrophy. After a long time, most of the patients develop antibodies against the drug and a lot of them against their natural leptin.

Another famous (among the pharma peptide community) case was Erythropoietin.

People developed immunity to proteins critical to production of red blood
cells, resulting in severe, life threatening immunity,

This wasn't discovered until they'd been using it for years, because at the clinical level, no one can check for antibodies like this. Only the trials were monitoring for immunogenicity, since it's expensive and complex.

It took over a decade to figure out what happened. The manufacturer of prefilled syringes started using tungsten pins to make holes in the syringe. This left behind atomic level traces of tungsten particles. The particles caused the protein to aggregate, and the immune system responded to these aggregates, developing an immunity to them, which unfortunately, looked very similar to the natural protein critical to red blood cell production.

 

[Ghoul]

Another famous (among the pharma peptide community) case was Erythropoietin.

People developed immunity to proteins critical to production of red blood
cells, resulting in severe, life threatening immunity,

This wasn't discovered until they'd been using it for years, because at the clinical level, no one can check for antibodies like this. Only the trials were monitoring for immunogenicity, since it's expensive and complex.

It took over a decade to figure out what happened. The manufacturer of prefilled syringes started using tungsten pins to make holes in the syringe. This left behind atomic level traces of tungsten particles. The particles caused the protein to aggregate, and the immune system responded to these aggregates, developing an immunity to them, which unfortunately, looked very similar to the natural protein critical to red blood cell production.

View attachment 316046

Meant to say they developed a severe, life threatening "anemia", as a result of immunity to a protein critical to red blood cell production.

 

[Hardcoreboy]

Ghoul, Can you help me, I have reached the maintenance dose with tirz and I was also going to use it all the time but can I take some other peptide to control hunger?

 

[Ghoul]

Ghoul, Can you help me, I have reached the maintenance dose with tirz and I was also going to use it all the time but can I take some other peptide to control hunger?

What dose of Tirz are you on? If it's UGL 15mg I'm confident you can increase to 20mg without issue.

Otherwise, taking a very small dose of Sema, midweek, can boost appetite suppression significantly if you need it.

So if your weekly Tirz dose is 15mg/Sunday. Try .10mg Sema on Wednesday.

That seems very low, but when using both, even a tiny dose of Sema can become too much really fast.

If not enough following week .20mg of Sema, etc.

 

[Hardcoreboy]

What dose of Tirz are you on? If it's UGL 15mg I'm confident you can increase to 20mg without issue.

Otherwise, taking a very small dose of Sema, midweek, can boost appetite suppression significantly if you need it.

So if your weekly Tirz dose is 15mg/Sunday. Try .10mg Sema on Wednesday.

That seems very low, but when using both, even a tiny dose of Sema can become too much really fast.

If not enough following week .20mg of Sema, etc.

Tirz about 20mg/wk now. I will try sema thanks!

 

[Ghoul]

Tirz about 20mg/wk now. I will try sema thanks!

I know you're eager for more appetite control, but trust me, tiny steps of Sema. May want to have some loperamide on hand (Imodium). The diarrhea from this combo can be brutal, even dangerous if you get too dehydrated. Would be best to take imodium at the first sign of it, usually within a day or two of the Sema shot.

Even a small dose of Sema is almost certain to kill any appetite you have.

 

[Luke391]

What dose of Tirz are you on? If it's UGL 15mg I'm confident you can increase to 20mg without issue.

Otherwise, taking a very small dose of Sema, midweek, can boost appetite suppression significantly if you need it.

So if your weekly Tirz dose is 15mg/Sunday. Try .10mg Sema on Wednesday.

That seems very low, but when using both, even a tiny dose of Sema can become too much really fast.

If not enough following week .20mg of Sema, etc.

what do you think of using other drugs to increase fat loss/reduce appetite on top of glps?
Not my current problem as this week I am feeling amazing on 5mg of tirzepatide but curious since the question popped up.
Like adding Tesofensine or Melanotan to reduce cravings or other drugs to increase lypholisis, such as L-Carnitine, Mots-C, SLU-PP-332, HGH, etc?

 

[Luke391]

I know you're eager for more appetite control, but trust me, tiny steps of Sema. May want to have some loperamide on hand (Imodium). The diarrhea from this combo can be brutal, even dangerous if you get too dehydrated. Would be best to take imodium at the first sign of it, usually within a day or two of the Sema shot.

Even a small dose of Sema is almost certain to kill any appetite you have.

yeah, Sema intestinal issues (constipation follower by the wrost diarreha of your life) can be brutal.
I did sema (ozempic pen) 2 years ago. Only used .25mg for 2 weeks and then stopped because it had me bedridden with the wrose nausea and stomach cramps of my life

 

[Ghoul]

what do you think of using other drugs to increase fat loss/reduce appetite on top of glps?
Not my current problem as this week I am feeling amazing on 5mg of tirzepatide but curious since the question popped up.
Like adding Tesofensine or Melanotan to reduce cravings or other drugs to increase lypholisis, such as L-Carnitine, Mots-C, SLU-PP-332, HGH, etc?

As long as it's a different mechanism of appetite suppression, like a stimulant, no problem. Anything that increases insulin sensitivity and lowers blood glucose, like Metformin. I'd avoid. GLPs work in a way that almost never causes hypoglycemia., but with another "diabetic treatment" drug you can push yourself into hypoglycemia and potentially damage the nerves in your eyes.

 

[Ghoul]

Also, if you're maxed out on the pharma dose of Sema or Tirz, and still have a significant way to go to ideal weight, get your Thyroid (TSH and Free T4) checked out. A lot of folks with weight issues seem to have hypothyroidism, and an appropriate dose of thyroxine often starts weight moving in the right direction without adding more weight loss drugs.

In the US TSH and Free t4 can be checked out for $40 via Ultalabtests, if you won't / can't have your doctor do it. This is especially true if you often feel lethargic and/or sensitive to cold.

 

[IronMetal_2]

I See acid reflux or GERD is a common side effect of all these drugs. I have had reflux issues before starting and or what ever reason, semaglutide actually helps my GERD. Tirzepatide made it worse.

I actually get less side effects on semaglutide right now than I did on tirzepatide.

Would always recommend to try both.

 

[Nidus]

Also, if you're maxed out on the pharma dose of Sema or Tirz, and still have a significant way to go to ideal weight, get your Thyroid (TSH and Free T4) checked out. A lot of folks with weight issues seem to have hypothyroidism, and an appropriate dose of thyroxine often starts weight moving in the right direction without adding more weight loss drugs.

In the US TSH and Free t4 can be checked out for $40 via Ultalabtests, if you won't / can't have your doctor do it. This is especially true if you often feel lethargic and/or sensitive to cold.

Would you consider 3.6 FT3 (ref range 2.5-4.2) and 1.64 T4 ref range 0.9-1.7 with a TSH value of 2.07 (ref range 0.27-4.20) normal?

 

[Ghoul]

Would you consider 3.6 FT3 (ref range 2.5-4.2) and 1.64 T4 ref range 0.9-1.7 with a TSH value of 2.07 (ref range 0.27-4.20) normal?

Looks pretty good actually.

 

[Luke391]

I See acid reflux or GERD is a common side effect of all these drugs. I have had reflux issues before starting and or what ever reason, semaglutide actually helps my GERD. Tirzepatide made it worse.

I actually get less side effects on semaglutide right now than I did on tirzepatide.

Would always recommend to try both.

every person adapts better to a acertain GLP. Fot me Sema was horrible, Tirzepatide has been amazing so far. Haven't used Reta but idk, maybe one day I might

 

[AlexDavis43]

A really known case for this is metreleptin use for lipodystrophy. After a long time, most of the patients develop antibodies against the drug and a lot of them against their natural leptin.

There were some editorials published about metreleptin/pramlintide and the study participants who lost weight. Many of them were able to maintain the weight loss.

It's different in the GLP1 trials because metreleptin/pramlintide studies employed dieticians who actively educated the participants on diet/lifestyle. That isn't a primary focus in GLP1 trials.

 

[Photon]

View attachment 316035

why not after getting at the full dose of tirzepatide (15mg or more) adding a low dose of survodutide to get additional GLP1 and Glucagon agonism wich lacks with tirzepatide? Glucagon agonism is especially beneficial for bone and liver health, and improve metabolism efficiency.

Did you compile this or was this found online?
If found online..were you able to fact check?

I'm having trouble verifying some of the figures..Take survo for e.g, the ratio I found was 8:1 (GLP/GCGR). Could you share the source for Survo Maz and Pam?

 

[anon55]

Did you compile this or was this found online?
If found online..were you able to fact check?

I'm having trouble verifying some of the figures..Take survo for e.g, the ratio I found was 8:1 (GLP/GCGR). Could you share the source for Survo Maz and Pam?

It's a chat GPT tabs, didn't really check deeper.

 

[egruberman]

GLPs have been used off label to treat women with nymphomania. I know it sounds like a joke, but it has. So consider yourself relieved of your sex addiction, lol.

Certainly didn't work for me.

Atozet (10MG Ezemtib/10mg Rosuvastin)

Pretty sure that's atorvastatin and ezetimibe. Ask your doctor for Rosuvastatin. I can explain why it's preferred if you like. There's no need to take the combo. If you want a combo, take the Rosuvastatin with Nexlizet. Start as low a dose as you can. Even still 10mg of Rosuvastatin is way more efficacious than 10mg Atorvastatin.

to increase lypholisis, such as L-Carnitine, Mots-C, SLU-PP-332, HGH, etc?

HGH is good, even synergistic with a GLP-1 RA. All those others, less so.

 

[Nidus]

Certainly didn't work for me.



Pretty sure that's atorvastatin and ezetimibe. Ask your doctor for Rosuvastatin. I can explain why it's preferred if you like. There's no need to take the combo. If you want a combo, take the Rosuvastatin with Nexlizet. Start as low a dose as you can. Even still 10mg of Rosuvastatin is way more efficacious than 10mg Atorvastatin.



HGH is good, even synergistic with a GLP-1 RA. All those others, less so.

He gave me Atozet (ezemtib with atorvastatin 10/10) only because thats what he had right away, actually got a prescription for 10mg Ezemtib and 5mg Rosuvastatin.

On top of that i got Metformin, 2x 500mg morning/evening and will start Tirza shortly with 10mg of Jardiance.

Going to run this for a month and then pull labs, expecting some major improvements overall. Non-Alcoholic Fatty Liver Disease runs big in my family and i want to be proactive as much as possible.

So thank you very much for the advice here!