MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
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Ghoul
Member
A "loss of effectiveness" regarding appetite suppression should involve regaining of weight unless the dose is increased, just like we see in the overwhelming cases weight rises after treatment is stopped.
I'm not seeing that anywhere, not in any studies, or in those in on a maintenance dose, where they should certainly suffer from a reduction in appetite suppression over long period of time at the same, weakening dose.
It's not like there's a lack of data here or multiple year experience with millions of long users.
Where are the "I lost weight at first but it stopped working and the weight came back" reports? If this is how it works, if a tolerance builds up, this is what the majority would experience.
I'm not seeing that anywhere, not in any studies, or in those in on a maintenance dose, where they should certainly suffer from a reduction in appetite suppression over long period of time at the same, weakening dose.
It's not like there's a lack of data here or multiple year experience with millions of long users.
Where are the "I lost weight at first but it stopped working and the weight came back" reports? If this is how it works, if a tolerance builds up, this is what the majority would experience.
anon55
Member
That's exactly what I thought. I'm at 20mg a week and can eat 3000kcal now. I'm not taking any weight, nor losing any. I'm maintaining my weight.
BrunoES
Member
I was thinking about the reports talking about appetite coming back.
Then I started thinking about how does a well regulated appetite work in a healthy human being.
Those people are taking something that would bring their appetite back to normality, so they end up losing weight.
As your weight gets closer to your healthy weight, plus you are on a deficit, you should get hunger signals, otherwise you would eventually die lol
Even people with the weakest appetite, IF they get lean enough AND are in a energy deficit, will feel hunger cues, expecting otherwise is hoping for the other extreme of an uncontrolled appetite, which could be just as harmful.
Just some thoughts lol
egruberman
Member
5mg weekly, fasted BG was 80 something, like 88mg/dL last I checked. HGH around 12iu daily. I don't track calories, just protein and watch the scale, which looked like this:
The bottom line is 170lbs and the divisions are 10lbs. I picked up some weight pretty quickly at first. Training consistency went to shit from thanksgiving to new years and so I backed off the food and since, I think I've leaned out some and gained little.
I mean you're pretty shredded, I wouldn't expect to loose weight naturally at 9% bf like you are
anon55
Member
What I mostly wanted to say is that even with a huge tirzepatide dose I still have appetite and don't lose or take weight. The peptide didn't lose his efficacy, I'm just at my maintenance dose.
yeah, seems like for you 20mg keeps you at single digit bf.
Are you using pharma grade mounjaro/zepbound or UGL Tirz?
The ugl stuff is probably weaker than the pharma grade
SnowyMiami
Member
Is there a source yet for pharma grade? I see Rybelsus (oral semaglutide) appearing in Turkish pharma but I have heard the sides are horrendous. I'm not touching chinesium garbage no matter how much Jano tests get thrown around.
anon55
Member
I'm using QSC tirzepatide. It works amazing, I started at 5mg and was barely able to eat for weeks..
This is very detailed, thank you. Fasting BG is actually pretty good, especially considering the 12ius of HGH (I'll be doing 8). Solid work brother!
egruberman
Member
I’ll be getting bloodwork soon. I’ll see where my HbA1C is at. If it’s not slightly elevated I’ll be surprised, but I still expect it to be within the normal range.
FWIW, 12iu in one bolus before bed.
subQ or IM GH ? whats your aas stack ?
Im doing the exact same protocol. Except tirz is at 4 mg/wk (e3.5d), gh at 10 ui daily pinned IM before bed. Recovery is amazing and BG is top notch. Cant say much about body composition because my AAS stack is kinda wet (1.8g total from which 1.1 is test). Managing e2 with adex and a bit of mast. Still wattery because test gh and slin here and there.
Experiencing with slin, thats not set in stone since tirz is supposed to do the job. It helps me get in the stupid amount of calories I need but in the meantime, it makes me retain a bit of water. Im a bit lost about that one.
D
I've always liked a bolus dose, but I can't do pre bed otherwise it messes with my sleep, so I do bolus a IM first thing in the morning.
It's reasonable to expect an elevation in A1C given that we're consuming more calories/carbs in a mass phase, but if these drugs can keep it all on the lower end/keep us more insulin sensitive I couldn't ask for more, lol.
You guys are making me want to up my HGH dose...
Last edited:
egruberman
Member
SubQ mostly, occasionally IM. I do have a reaction sometimes, but it's not consistent.
AAS stack is test and primo. I'm afraid to mentioned doses because I don't want anyone to believe what I"m doing is reasonable for them. 2:1 test C to primo and let's just say, "grams".
I don't know how can you manage that volume of oil xD
egruberman
Member
In terms of sides or PIP? Sides have been non-existent to the extent that it is difficult to believe. The volume of oil has been 2ml per day and it's been fine for the most part, but I'm happy to be done.
Sides are personal, it's the volume of oil to inject that it's a pain in the ass. I like primo but due to the max concentration of 200mg I fucking hate it.
2ml ED gets old so fast, at least for me
egruberman
Member
Yup. I split mine into two injections using 1ml syringes and like previous blasts, no problems with PIP until 2/3 through and then every third or fourth day.
Rybelsius, even pahrma grade, is quite crap. wrose appetite suppression than sema and worse side effects + liver damage
Ghoul
Member
And the UGL/compounded stuff is less than worthless, since they don't have the absorption enhancers that allow even the tiny bit that manages to get absorbed from the pharma version get through.
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