I may have to look into this….so does this have the possibility of lessening substance use? All substances?
The TLDR version from what I've seen from my own casual observation, personal experience, what much of the early research into this aspect of GLPs is pointing to, and what's now been clinically proven to the point of Sema getting FDA approval to treat alcoholism is this:
GLP receptor activation in the brain seems to reduce the drive behind many forms of compulsive behavior.
We know the impact on overeating, besides physical appetite reduction effects on digestion, there is a less well understood, despite the mockery from the willfully ignorant, a lowering of "food noise", shorthand for the psychological drive to seek out food. Something most people don't realize is there until it isn't. It's not brought up because it's an "excuse", it's because it's startling and unexpected when you experience it. I've done just about every hallucinogen out there, at heroic doses, and I don't think I've ever felt such a profound, lasting change from any of them that compares to that.
Whatever that mechanism is, it appears to be shared with addictions of all types.
Alcoholism is confirmed to be significantly impacted and GLPs will likely become first line treatment. It's more effective than AA meetings or behavioral counseling.
Anecdotally, cannabis, cocaine, nicotine, even gambling and shopping addictions all seem to be lessened or eliminated after initiation of GLP use thus far.
I personally know a woman who could never, ever leave her pot vape behind. She told me that one day a month or so after starting Sema, she was leaving her house and noticed the vape on a table. Instead of going back to get it she thought. "meh, whatever", and left without it. When she got home she said it was like she was seeing it for the first time and just wasn't interested in it anymore.
Many behaviors, when people are compelled to do them to excess, are linked to dopamine and the reward system we evolved to do the things necessary for survival. So it stands to reason if GLPs are doing something to the brain to correct that dysfunction, it's affecting everything related to it.