High hemoglobin -> aspirin?

[Type-IIx]

Donate blood or get a doctor phlebotomy. Aspirin or blood thinners won't do anything.

They reduce clotting and therefore the risk of a thromboembolic event. They don't reduce red cell count/hemoglobin/hematocrit levels.

I basically agree that phlebotomy is usually a better practice if you can manage it therapeutically.

 

[S.B.C]

The medical philosophy in my country is very restrictive. They only offer aspirins to people with previous clotts. Not in a preventable manner

isn't aspirin otc the world over ? which country do u live in ? I'll happily mail u a pack if u really can't get it locally.

 

[Mads]

isn't aspirin otc the world over ? which country do u live in ? I'll happily mail u a pack if u really can't get it locally.

Hey Mate im located in nazi Denmark, but aspirin is scripfree. I was just wondering the risk v reward since alot of big guys seem to run it. Thanks tho

 

[S.B.C]

I've been taking baby aspirin on and off for years thanks to this forum I've realized that was dumb as there's a rebound risk every time I stop. My doc also tells me not to worry about my high readings but that just adds to my worry

 

[PeterBond]

Nobody can stand in your shoes and determine whether the tradeoffs between efficacy and tolerability make sense for you to take it.

Here is what you need to actually know to do this balancing of interests for yourself:

Aspirin doses of 80 - 100 mg daily ("daily low dose Aspirin") broadly reduce cardiovascular disease risk rather than lowering HCT. It prevents clotting by inhibiting cyclooxygenase (COX) enzyme in thrombocyte (platelets), thereby ↓thrombotic but ↑bleeding risk. Daily, low dose Aspirin is not recommended by European Guidelines, that are known for risk averseness versus North American medical recommendations. There is a risk of rebound upon cessation/withdrawal if you are to stop the daily low dose Aprisin, in the form of an increased risk of a thrombotic event for weeks after Aspirin discontinuation.

The absolute risks of thromboembolic events are low for otherwise healthy men with mild erythrocytosis/polycythymia characteristic of TRT or AAS use. For normal men, the
while the relative risk seems tremendous in that for every 5% ↑ in haematocrit, there was a 33% ↑ in the probability for a venous thromboembolic event in men, adjusted for age, BMI, and smoking, the picture is quite different in terms of absolute risk.

In terms of absolute risk of a thromboembolic event in normal/healthy men with average haematocrit (43 - 46%), there is a 0.16% probability for such an event within 10 years (1.6 per 1,000 person-years). If haematocrit ↑ by 5%, that chance ↑ by 33% to 0.21% within the next 10 years (2.1 per 1,000 person-years).

All of this information comes from @PeterBond's Book on Steroids. It should be required reading for every AAS user in my view. I believe that it qualifies as light reading for an average university-educated person, and can be used a reference for all sorts of questions that arise on a daily basis on this forum.

While Aspirin on an empty stomach can hurt the stomach lining, besides that, daily low dose Aspirin is regarded as quite safe for the kidneys and liver. It actually enhances/increases bloodflow to the extremities, one important mechanism in its reduction of CVD risk.

When I was writing my book I flipped the bold-faced parts between annual and 10-year risk a couple of times. Regrettably, the annual statistics are given instead of the 10-year statistics. So the 0,21 and 0,16% should be multiplied by 10. It's corrected in the second edition and I bumped into it around the time I was writing this article:

Anabolic Steroids and Erythrocytosis Polycythemia

The use of anabolic steroids can lead to a condition called erythrocytosis. It’s a condition in which your body has too many erythrocytes, or red blood cells, in its blood.

thinksteroids.com

(I was frowning my eyebrows when I was including those statistics in the article and, fortunately, ended up not trusting my own writing so I double-checked it.)

 

[Type-IIx]

When I was writing my book I flipped the bold-faced parts between annual and 10-year risk a couple of times. Regrettably, the annual statistics are given instead of the 10-year statistics. So the 0,21 and 0,16% should be multiplied by 10. It's corrected in the second edition and I bumped into it around the time I was writing this article:

Anabolic Steroids and Erythrocytosis Polycythemia

The use of anabolic steroids can lead to a condition called erythrocytosis. It’s a condition in which your body has too many erythrocytes, or red blood cells, in its blood.

thinksteroids.com

(I was frowning my eyebrows when I was including those statistics in the article and, fortunately, ended up not trusting my own writing so I double-checked it.)

Oh, wow, thank you for this clarification!

 

[Juicedhead]

They reduce clotting and therefore the risk of a thromboembolic event. They don't reduce red cell count/hemoglobin/hematocrit levels.

I basically agree that phlebotomy is usually a better practice if you can manage it therapeutically.

yeah man get a lobotomy, better practice forsure.

 

[Type-IIx]

yeah man get a lobotomy, better practice forsure.

My receiving a lobotomy would be the only method by which I could learn to communicate with you on the same level, and not have to work hard at dumbing shit down past the point of lost meaning.

 

[Juicedhead]

My receiving a lobotomy would be the only method by which I could learn to communicate with you on the same level, and not have to work hard at dumbing shit down past the point of lost meaning.

would you say its a valid argument that eating pussy would increase protein intake in roden models? Im trying to get this to human trials.

 

[Type-IIx]

would you say its a valid argument that eating pussy would increase protein intake in roden models? Im trying to get this to human trials.

Juicedhead is the bushman of the Calahari!

Whistlin' in the wheatfields!

South of the Boooooddddaaahh, where the tuna fish plaaaaaaaay.

Remember, if you'll suck on pussy, you'll basically suck on anything. And if you fuck with me while I'm on Tren and your lil ball-bag atrophies in your hospital bed, I'm cuckolding you with your gaggle of fuckboi whores, Juicedhead.

 

[Juicedhead]

Juicedhead is the bushman of the Calahari!

Whistlin' in the wheatfields!

South of the Boooooddddaaahh, where the tuna fish plaaaaaaaay.

Remember, if you'll suck on pussy, you'll basically suck on anything. And if you fuck with me while I'm on Tren and your lil ball-bag atrophies in your hospital bed, I'm cuckolding you with your gaggle of fuckboi whores, Juicedhead.

ok, commencing human trials.

Edit: But seriously leave the whores out of this ok? And my ball bag is bigger than yours I've been off gear and I did a bioscience based PCT backed by bioscience. Also Im out of the hospital and I'm still more jacked than you, type-II. And also, I got my spell checked fixed... BOOOOOYAAAAAA GRANDMAAA

 

[clearheaded]

They reduce clotting and therefore the risk of a thromboembolic event. They don't reduce red cell count/hemoglobin/hematocrit levels.

I basically agree that phlebotomy is usually a better practice if you can manage it therapeutically.

it does lower ferritin however, which of course depending on your starting point it could be limiting factor for hemocrit/RCC/HG could it not? ie become more anemic. not disagreeing practically, just something to consider and may be a benefit for some, detriment for others.

 

[DECLAN]

Hey Mate im located in nazi Denmark, but aspirin is scripfree. I was just wondering the risk v reward since alot of big guys seem to run it. Thanks tho

I run into high hemoglobin/hematocrit and I have naturally high rbcs. I stopped trt for two months and even took daily small dose aspirin 80mg, both didn't help.

Everything went down after I donated blood. Now, I give blood whenever I can, it is good to help as well.

Be sure to be well hydrated before you take the test though, I tested a little off 2 months ago because I went in after work and was mildly dehydrated I think.

 

[Type-IIx]

it does lower ferritin however, which of course depending on your starting point it could be limiting factor for hemocrit/RCC/HG could it not? ie become more anemic. not disagreeing practically, just something to consider and may be a benefit for some, detriment for others.

Mechanistically, yes; with clinical significance, no.

 

[Jin23]

it does lower ferritin however, which of course depending on your starting point it could be limiting factor for hemocrit/RCC/HG could it not? ie become more anemic. not disagreeing practically, just something to consider and may be a benefit for some, detriment for others.

Ferritin is only indirectly related to hgb. In regards to iron metabolism, serum iron is what matters for hgb and not ferritin. It is very much possible to have normal, or even high ferritin, but low serum iron and low hgb, due to inflammation. Or you could have low ferritin and high hgb due to high iron uptake, caused by low hepcidin due to high testosterone ...

Aspirin causes gi micro bleeding, thus essentially lowering iron with blood loss. So this is loosing serum iron, which then, if hepcidin is low enough, stimulates iron release from ferritin. I'm not too studied upon aspirin though, so there might be some secondary or tertiary moa's of which I don't know ... But the gi bleeding always seemed like a rather nasty way of lowering iron/hgb.