Injectable eaa

[Kgkle]

So I was looking for some info eaa and found this:

Nephramine (Essential Amino Acid Injection): Side Effects, Interactions, Warning, Dosage & Uses

What’s your thoughts?

 

[Skull]

^^^ @Wunderpus ^^^

I didn't even know they made injectable EAA's

 

[Endure]

Really interesting, anyone ever tried?

 

[Wunderpus]

So I was looking for some info eaa and found this:

Nephramine (Essential Amino Acid Injection): Side Effects, Interactions, Warning, Dosage & Uses

What’s your thoughts?

Rumor has it that this process has been used for high level pros for a long time, including intravenous EAAs w/ insulin.... Never seen it personally, so, who knows? But, it's a wild rumor if it's out of thin air.

 

[Eman]

This is my preferred method for amino acid intake:

 

[Wunderpus]

This is my preferred method for amino acid intake:

View attachment 84601

You know.... I've been trying to take leucine in with every protein meal as a number of respected people seem to suggest. I really do think it's helped with the protein absorption....

 

[Eman]

You know.... I've been trying to take leucine in with every protein meal as a number of respected people seem to suggest. I really do think it's helped with the protein absorption....

I think my multi has leucine so I might be doing this too inadvertently.

 

[Wunderpus]

I think my multi has leucine so I might be doing this too inadvertently.

"Ingesting 23 g of protein with 5 g of added leucine achieved near-maximal FSR after endurance exercise, an effect unlikely attributable to mTORC1-S6K-rpS6 signaling, insulin, or amino acids. Translating the effects of protein-leucine quantity onprotein synthesis to optimizing adaptation and performance requires further research."
Protein-leucine fed dose effects on muscle protein synthesis after endurance exercise. - PubMed - NCBI

"Leucine co-ingestion with a bolus of pure dietary protein further stimulates post-prandial muscle protein synthesis rates in elderly men."
Leucine co-ingestion improves post-prandial muscle protein accretion in elderly men. - PubMed - NCBI

"We conclude that coingestion of protein and leucine stimulates muscle protein synthesis and optimizes whole body protein balance compared with the intake of carbohydrate only."
Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. - PubMed - NCBI


So, there's beyond enough evidence to support it's addition to protein intake....

 

[Docd187123]

"Ingesting 23 g of protein with 5 g of added leucine achieved near-maximal FSR after endurance exercise, an effect unlikely attributable to mTORC1-S6K-rpS6 signaling, insulin, or amino acids. Translating the effects of protein-leucine quantity onprotein synthesis to optimizing adaptation and performance requires further research."
Protein-leucine fed dose effects on muscle protein synthesis after endurance exercise. - PubMed - NCBI

"Leucine co-ingestion with a bolus of pure dietary protein further stimulates post-prandial muscle protein synthesis rates in elderly men."
Leucine co-ingestion improves post-prandial muscle protein accretion in elderly men. - PubMed - NCBI

"We conclude that coingestion of protein and leucine stimulates muscle protein synthesis and optimizes whole body protein balance compared with the intake of carbohydrate only."
Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. - PubMed - NCBI


So, there's beyond enough evidence to support it's addition to protein intake....

The evidence posted here is on pretty weak footing 'Pus.

Study 1 compared 75g protein and 15g Leucine to 23g protein and 5g leucine and no protein/no leucine. It's to be expected that MPS will be higher when you basically triple one's protein intake.

Study 2 was done on very elderly patients who's needs differ from ours and again, compared leucine and protein to just leucine with no protein. Of course an extra 20g of protein is going to make a difference

Study 3 did protein infusion which significantly alters things when compared to getting protein in the diet.

I know myself as well as many others like Zilla, Rockwell, Dr. Scally and Jim, CBS, etc also have mentioned that taking results from studies in an acute setting and applying them to chronic,long term results can be tricky. The body has a way of compensating for these small differences in the big picture so while these studies are interesting of course, there's still a lot left to be desired.

 

[Eman]

This is an interesting abstract, written by a L. Notion... Who docd is a complete slut for.

Leucine Regulates Translation Initiation of Protein Synthesis in Skeletal Muscle after Exercise | The Journal of Nutrition | Oxford Academic

 

[Wunderpus]

The evidence posted here is on pretty weak footing 'Pus.

Study 1 compared 75g protein and 15g Leucine to 23g protein and 5g leucine and no protein/no leucine. It's to be expected that MPS will be higher when you basically triple one's protein intake.

Study 2 was done on very elderly patients who's needs differ from ours and again, compared leucine and protein to just leucine with no protein. Of course an extra 20g of protein is going to make a difference

Study 3 did protein infusion which significantly alters things when compared to getting protein in the diet.

I know myself as well as many others like Zilla, Rockwell, Dr. Scally and Jim, CBS, etc also have mentioned that taking results from studies in an acute setting and applying them to chronic,long term results can be tricky. The body has a way of compensating for these small differences in the big picture so while these studies are interesting of course, there's still a lot left to be desired.

This boils down to "does it hurt, or potentially help?" for me... Can leucine supplementation "hurt"? Probably not. Can it POTENTIALLY boost protein absorption -> synthesis? Maybe... Worth it? Totally.

 

[Docd187123]

This boils down to "does it hurt, or potentially help?" for me... Can leucine supplementation "hurt"? Probably not. Can it POTENTIALLY boost protein absorption -> synthesis? Maybe... Worth it? Totally.

Very little risk of it hurting you. You’d probably have to be taking gallons of the shit and be on dialysis for it to really hurt you.

 

[Wunderpus]

Very little risk of it hurting you. You’d probably have to be taking gallons of the shit and be on dialysis for it to really hurt you.

Good luck, it tastes like camel's cunt... I have to plug my nose if I mix leucine and NaC in the same shake.

 

[Docd187123]

Good luck, it tastes like camel's cunt... I have to plug my nose if I mix leucine and NaC in the same shake.

I can’t stand NAC. Tried it twice and never again.