anon55
Member
We have all heard tons of stories of why diuretics are so toxic, and people fainting before of just after a competition.
That's because of gigantic doses of loop diuretics usually, it makes you pee all you minerals.
But saying diuretics are bad is like saying fat are bad. Yeah industrial trans-fats are, but PUFA are great for example.
The main risk in general is dehydration, more precisely hypovolemia which causes stress of organs and mostly on the kidneys. But if you look at MR blockers like eplerenone, you will pee so little more that you won't notice it. In fact, eplerenone is beneficial for us against kidneys and heart damage caused by aldosterone, hypertension and AAS.
Yeah your potassium will go up. It is dangerous? No. Not really, just need monitoring at the beginning, like monitoring sometimes liver values on a statin.
Indapamide is really effective for BP, is bone protective and reduces the risk of kidney stone. Chlortalidone is similar, but stronger.
Amiloride is weak but promotes natriuresis through the day, making you look leaner and better
Some however should really be used with caution, or not used at all.
- hydrochlorothiazide: diabetogenic, fucks lipids, make you lose almost all electrolytes
- furosemide or torsemide: only in emergency situations associate with huge edemas, powerful, can worsen water retention
- Tolvaptan: make you pee all your water but without sodium loss. Unbearable and liver-toxic.
- Spironolactone: blocks MR, AR, PR. Strongest diuretic among MR blocker, but you will pee your muscles and get gyno.
- Finerenone : not a diuretic! But beneficial.
Beware if using potassium sparing diuretics with a sartan. Potassium level++
Beware if using non-potassium sparing diuretics without potassium sparing diuretics: potassium--, even more if using beta2 agonist.
That's because of gigantic doses of loop diuretics usually, it makes you pee all you minerals.
But saying diuretics are bad is like saying fat are bad. Yeah industrial trans-fats are, but PUFA are great for example.
The main risk in general is dehydration, more precisely hypovolemia which causes stress of organs and mostly on the kidneys. But if you look at MR blockers like eplerenone, you will pee so little more that you won't notice it. In fact, eplerenone is beneficial for us against kidneys and heart damage caused by aldosterone, hypertension and AAS.
Yeah your potassium will go up. It is dangerous? No. Not really, just need monitoring at the beginning, like monitoring sometimes liver values on a statin.
Indapamide is really effective for BP, is bone protective and reduces the risk of kidney stone. Chlortalidone is similar, but stronger.
Amiloride is weak but promotes natriuresis through the day, making you look leaner and better
Some however should really be used with caution, or not used at all.
- hydrochlorothiazide: diabetogenic, fucks lipids, make you lose almost all electrolytes
- furosemide or torsemide: only in emergency situations associate with huge edemas, powerful, can worsen water retention
- Tolvaptan: make you pee all your water but without sodium loss. Unbearable and liver-toxic.
- Spironolactone: blocks MR, AR, PR. Strongest diuretic among MR blocker, but you will pee your muscles and get gyno.
- Finerenone : not a diuretic! But beneficial.
Beware if using potassium sparing diuretics with a sartan. Potassium level++
Beware if using non-potassium sparing diuretics without potassium sparing diuretics: potassium--, even more if using beta2 agonist.
