Selegiline

[MrGrant]

Looking for feedback on Selegiline from people (ideally) over 40 who use it to either feel good, anti aging or any other reason not prescribed by a doctor.

In other threads its mentioned to work well with modafinil for that get up and go feeling so any anecdotal thoughts on this please share, not soo interested in anti aging (I'm 61 so a bit late to start worrying about getting slow and weak coz I already am, but want to enjoy things as much as possible for now).
I currently take around 200mg moda and sometimes 50mg amoda a day and looking for things that may help without being too hard on the body (Also on "TRT", statin, aspirin, lager and the occasional big night out (and 4 days in bed after).

Thread 'Operation Pangea XVII: Record 769 arrests and USD 65 million in illicit pharmaceuticals seized in global bust'

Jun 26, 2025

Record 769 arrests and USD 65 million in illicit pharmaceuticals seized in global bust

Operation reveals growing demand for semaglutides and peptides as ‘lifestyle enhancers’

www.interpol.int

• kain
• Replies: 35
• Forum: Steroid News Forum

• 

 

[eryximachus]

I've tried it. It does nothing for me. There are sources here that sell Parnate, which according to Ken Gillman the MAOI God King is the best. I have not tried it, but Ken's work at psychotropical.com is interesting if you want to pursue this rabbit hole more.

Not sure how seligiline got into the bodybuilding world. I strongly suspect it was one random study that can blown way out of proportion.

 

[Duke309]

I didn't like how selegiline makes me feel though I love the idea of it in an anti-aging perspective.

 

[Ghoul]

5mg / day works very well for me. A couple of weeks to take full effect. (I started 2.5/day the first week, but in hindsight I doubt it's necessary).

I wouldn't want to go without it.

Have to dial back caffeine or any other stimulant (not due to contraindication, just that Selegiline makes you much more sensitive to them).

The effect drops off slightly in the first month and then stabilizes. It doesn't create a tolerance that requires higher doses.

DO NOT USE THIS IF TAKING AN SSRI.

 

[RockyP]

IIRC seleg is a selective MAO-B inhibitor and as such does not require as much dietary restriction as something like Parnate. But as Ghoul said, you really need to do your homework about what you are taking, PEDs and other meds, and be damn sure there are no contraindications. Stims would not be contraindicated, but you need to be very gentle with them if you start seleg. IMO this is not something that should be in a PED user's toolbox if they can help it, though if you are not using thyroid, clen, yohimbine, other stims, etc. it should be ok (again, check any other meds / supplements - most pre-workouts for example say do not take if you are on MAOI)

I would not mess with Parnate or other non-selective MAOI's unless you are under the care of someone who knows what they are doing, which is a real chore to find since most psychiatrists are dangerous at best.

 

[IndividualMan]

5mg / day works very well for me. A couple of weeks to take full effect. (I started 2.5/day the first week, but in hindsight I doubt it's necessary).

I wouldn't want to go without it.

Have to dial back caffeine or any other stimulant (not due to contraindication, just that Selegiline makes you much more sensitive to them).

The effect drops off slightly in the first month and then stabilizes. It doesn't create a tolerance that requires higher doses.

DO NOT USE THIS IF TAKING AN SSRI.

got it. sertraline 50mg daily, 2 mg tesofensine daily, Fluvoxamine, 300mg Fladrafinil, and 5mg selegiline 2xdaily.

Also, occasional cocaine and methamphetamine use. for maximum efficacy.

 

[Ghoul]

IIRC seleg is a selective MAO-B inhibitor and as such does not require as much dietary restriction as something like Parnate. But as Ghoul said, you really need to do your homework about what you are taking, PEDs and other meds, and be damn sure there are no contraindications. Stims would not be contraindicated, but you need to be very gentle with them if you start seleg. IMO this is not something that should be in a PED user's toolbox if they can help it, though if you are not using thyroid, clen, yohimbine, other stims, etc. it should be ok (again, check any other meds / supplements - most pre-workouts for example say do not take if you are on MAOI)

I would not mess with Parnate or other non-selective MAOI's unless you are under the care of someone who knows what they are doing, which is a real chore to find since most psychiatrists are dangerous at best.

The only thing that raises Seleg above the risk level of Tylenol is at doses above 10mg it starts to have an MAO-A inhibition effects (leading to potentially excessively high serotonin), and the you'd have the standard "avoid aged cheese" type SSRI precautions.

5mg is well below that level and makes those concerns a non issue. Parkinson's patients take it for decades without issue. It's got an excellent long term safety record compared to almost everything else.

 

[RockyP]

The only thing that raises Seleg above the risk level of Tylenol is at doses above 10mg it starts to have an MAO-A inhibition effects (leading to potentially excessively high serotonin), and the you'd have the standard "avoid aged cheese" type SSRI precautions.

5mg is well below that level and makes those concerns a non issue. Parkinson's patients take it for decades without issue. It's got an excellent long term safety record compared to almost everything else.

I believe the EMSAM patches were very popular among the FTX crew (along with other stims). Agree it’s rather safe but as you said would be mindful of other stims when using it.

 

[Ghoul]

I believe the EMSAM patches were very popular among the FTX crew (along with other stims). Agree it’s rather safe but as you said would be mindful of other stims when using it.

I was going to mention that. But those are much, much higher doses than the numbers suggest, even though they don't seem like it. starting at only 6mg.


Oral bioavailability of Seleg tablets is 10%.

Bioavailability of EMSAM patches is 75%!

So effectively, a 6mg patch is equivalent to 12 x 5mg tablets!

 

[buck]

I have been using selegiline for well over 15 years for it's supposed anti aging effects. I started with relatively low dose and have gone up as the years go by. Hard to say how well it works as i only have me to go by.

 

[Ghoul]

I have been using selegiline for well over 15 years for it's supposed anti aging effects. I started with relatively low dose and have gone up as the years go by. Hard to say how well it works as i only have me to go by.

Walking pace is one measure of "dopaminergic" condition.

Next time you're in a store parking lot compare yourself to similar age peers and make a mental note if you're walking faster than most others....

Barring some physical issue that inhibits walking, it's surprisingly accurate proxy measure for "biological age" that's used in quite a few studies.

My 85 yo father in law has always been the picture of perfect health, and one thing I noticed was his default walking speed was always "hauling ass" compared to everyone else lol.

 

[eryximachus]

5mg / day works very well for me. A couple of weeks to take full effect. (I started 2.5/day the first week, but in hindsight I doubt it's necessary).

I wouldn't want to go without it.

Have to dial back caffeine or any other stimulant (not due to contraindication, just that Selegiline makes you much more sensitive to them).

The effect drops off slightly in the first month and then stabilizes. It doesn't create a tolerance that requires higher doses.

DO NOT USE THIS IF TAKING AN SSRI.

I'm sure you of all people knows the drug has very poor oral availability. That is why a transdermal patch was manufactured. Seems like a placebo effect.

The only supposed benefit of the drug is it is "safer" than other, more clinically effective MAOI drugs. But the risks are way overblown for MAOIs (which Ken Gillman documents extensively).

 

[RockyP]

There's only one way to know the truth about this drug. Ask Todd Lee and then do the opposite.

 

[Duke309]

got it. sertraline 50mg daily, 2 mg tesofensine daily, Fluvoxamine, 300mg Fladrafinil, and 5mg selegiline 2xdaily.

Also, occasional cocaine and methamphetamine use. for maximum efficacy.

man don't give vigorous steve any ideas.

 

[BamaCrazy]

I have been using selegiline for well over 15 years for it's supposed anti aging effects. I started with relatively low dose and have gone up as the years go by. Hard to say how well it works as i only have me to go by.

What dose are you now taking?

 

[buck]

Walking pace is one measure of "dopaminergic" condition.

Next time you're in a store parking lot compare yourself to similar age peers and make a mental note if you're walking faster than most others....

Barring some physical issue that inhibits walking, it's surprisingly accurate proxy measure for "biological age" that's used in quite a few studies.

My 85 yo father in law has always been the picture of perfect health, and one thing I noticed was his default walking speed was always "hauling ass" compared to everyone else lol.

I have been training and eating healthy all my life so being physically ahead of my peers is not much of a measure to see if selegiline is working.

It is the rare 20 year old that will pass me on my daily walks these . Now climbing up the side of a mountain will see the kids passing me. But they are a far more athletic group then most of the population.

Been doing aerobics to some degree all my life. Running and biking when i was younger. Hiking mountain climbing, back counrty skiing through mid life if i am desperate i may do something indoors. Mostly LISS these days with walking and some HIIT thrown in . My VO2 max has averaged about 130% for my age group all my life.

 

[Duke309]

I was going to mention that. But those are much, much higher doses than the numbers suggest, even though they don't seem like it. starting at only 6mg.


Oral bioavailability of Seleg tablets is 10%.

Bioavailability of EMSAM patches is 75%!

So effectively, a 6mg patch is equivalent to 12 x 5mg tablets!

Sublingual administration raises the bioavailability substantially compared to oral too.

 

[Deadpool99]

5mg / day works very well for me. A couple of weeks to take full effect. (I started 2.5/day the first week, but in hindsight I doubt it's necessary).

I wouldn't want to go without it.

Have to dial back caffeine or any other stimulant (not due to contraindication, just that Selegiline makes you much more sensitive to them).

The effect drops off slightly in the first month and then stabilizes. It doesn't create a tolerance that requires higher doses.

DO NOT USE THIS IF TAKING AN SSRI.

I was thinking of ways to reduce my fatigue and give me some energy, Modafinil seems to cause insomnia which is the worst thing for me. I don't get any on clen/tren high doses but moda works differently.

Do you think it's worth exploring Selegiline 5mg oral will help with boost energy and not feeling drowsy like moda would do? Probably not to the same extent but will it be worth adding for that reason?

 

[Duke309]

I was thinking of ways to reduce my fatigue and give me some energy, Modafinil seems to cause insomnia which is the worst thing for me. I don't get any on clen/tren high doses but moda works differently.

Do you think it's worth exploring Selegiline 5mg oral will help with boost energy and not feeling drowsy like moda would do? Probably not to the same extent but will it be worth adding for that reason?

I got more of an "anti-fatigue" effect from methylene blue rather than selegiline. I have had a few nights when using it that it was harder to sleep however.

 

[Ghoul]

I was thinking of ways to reduce my fatigue and give me some energy, Modafinil seems to cause insomnia which is the worst thing for me. I don't get any on clen/tren high doses but moda works differently.

Do you think it's worth exploring Selegiline 5mg oral will help with boost energy and not feeling drowsy like moda would do? Probably not to the same extent but will it be worth adding for that reason?

Try it. Taken in the morning it won't interfere with sleep. Just keep in mind it takes a week or two for its full effect to develop. If your fatigue is a result of dopamine depletion, it'll help, without acting as a stimulant (though it will amplify and prolong any stimulants you use, so keep that in mind. IE, a cup of coffee would now be the equivalent of 1.5-2x cups.).