Metformin for insulin sensitivity and muscle growth

[MESO-Rx Administrator]

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[BigDadd7]

i'm already fairly lean, i want to ideally build muscle and i don't want anything interfering with that.

Diet and exercise determine that. No offense, but a skinny guy needing drugs is pathetic.

 

[BigDadd7]

It’s just not relevant in the scheme of things, John Jewett has said he takes 1000mg prophylactically. Cunts a top 10 Olympian.

Are you retarded? You joined here to give out this kind of advice to scrawny kids?

 

[syuri]

welp. atleast you guys are honest thanks either way

 

[namsn]

I use it. Definitely makes a difference for pumps and overall recovery.

 

[MapleAUS]

Are you retarded? You joined here to give out this kind of advice to scrawny kids?

Did I say to take it?

Did I?

There is a question about whether metformin is going to stop your muscle gain. The answer is no. If someone else wants to know about the topic, and uses the search function, they now have an answer.

I’m not going to limit the information I provide due to the fact it could be used in the wrong circumstances. People must just weigh pros and cons of every drug decision they pose.

If someone’s mind is set on something, you’re not going to be able to forcefully change their mind. If anything, look at my next message, I related his current situation to my own, stated how I didn’t need it etc, and probably convinced him more than you’d be able to by stating “you’re a skinny fuckwit bro kill yourself before trying drugs to get bigger”.

 

[MapleAUS]

really? yeah you're probably right about me overthinking shit.

hate to keep asking things but could i ask what cycles you've done? not looking for what i'm gonna do next lol, but i'm curious about what got you from 185 - 225. sounds like amazing progress. thanks

Started 250 test, every cycle was higher until now I use 500 test 250 EQ. Rare orals throughout the whole process.

Should you do this? No, but I’m stating this to show you really don’t need too much gear, and what the boys have been saying about training, diet, etc, is all correct, you also need to factor in TIME. Time and consistency is more important than anything.

 

[BigDadd7]

Did I say to take it?

Did I?

There is a question about whether metformin is going to stop your muscle gain. The answer is no. If someone else wants to know about the topic, and uses the search function, they now have an answer.

I’m not going to limit the information I provide due to the fact it could be used in the wrong circumstances. People must just weigh pros and cons of every drug decision they pose.

If someone’s mind is set on something, you’re not going to be able to forcefully change their mind. If anything, look at my next message, I related his current situation to my own, stated how I didn’t need it etc, and probably convinced him more than you’d be able to by stating “you’re a skinny fuckwit bro kill yourself before trying drugs to get bigger”.

Dont play stupid

 

[MapleAUS]

Dont play stupid

Your inability to read does not have an effect on my ability to write

 

[dinfar1337]

114 right after waking (on a low carb day) usually its 138

dude just get on insulin

 

[Banana Joe]

welp. atleast you guys are honest thanks either way

Don't a shot for one week, then go continue with 150mg ew. Start researching how to do a proper PCT TODAY and before you order the next drug, ask in the forums. As soon as you have the PCT drugs, you STOP the Test injections and begin with the PCT.

Get bloodwork multiple times regarding your hormones. Too bad you fugged up, and likely have no before bloodwork, so you will never know if and how much you fukced yourself.

Go see a doctor because of your (pre-?)diabetes. Don't try to treat it yourself, you are not capable of that.
Still. start doing proper cardio.

Start to become ferocious about and with your training. Finally learn how to eat.

Come back in a few YEARS, when ALL this is not only understood and reflected upon, but dialed in, and have gained 40lbs, with not significantly higher body fat than you have now. Get a cheap caliper and keep measuring your skin fold next to the belly button, as well as a measuring tape. This way you can gauge your weight gain. And take progress photos, you will see if you gotten fat.
Then you *might* be in a position to run a 350mg Test cycle.

Good luck!

 

[Shredster]

Don't a shot for one week, then go continue with 150mg ew. Start researching how to do a proper PCT TODAY and before you order the next drug, ask in the forums. As soon as you have the PCT drugs, you STOP the Test injections and begin with the PCT.

Get bloodwork multiple times regarding your hormones. Too bad you fugged up, and likely have no before bloodwork, so you will never know if and how much you fukced yourself.

Go see a doctor because of your (pre-?)diabetes. Don't try to treat it yourself, you are not capable of that.
Still. start doing proper cardio.

Start to become ferocious about and with your training. Finally learn how to eat.

Come back in a few YEARS, when ALL this is not only understood and reflected upon, but dialed in, and have gained 40lbs, with not significantly higher body fat than you have now. Get a cheap caliper and keep measuring your skin fold next to the belly button, as well as a measuring tape. This way you can gauge your weight gain. And take progress photos, you will see if you gotten fat.
Then you *might* be in a position to run a 350mg Test cycle.

Good luck!

jfl at this gatekeeping. The user in question is retarded however that doesn't negate the fact that your claims are preposterous. JFL at thinking you can put on close to 40 lbs of muscle in 2 years (implied by the not significantly higher body fat)

A cheap caliper in the hands of an inexperienced user will yield inaccurate and inconsistent results.

I understand you are trying to help but get off this high air of arrogance and try to provide actual helpful advice instead of misinformation and false hopes

 

[ChemBB]

Here's an actual answer:

Look up the "MASTERS" trial results for why you don't want to use metformin.

 

[MapleAUS]

Here's an actual answer:

Look up the "MASTERS" trial results for why you don't want to use metformin.

Am I incorrect in saying this is only applicable to an older population?

 

[dinfar1337]

Am I incorrect in saying this is only applicable to an older population?

nope.

you got it, and the muscle growth difference weren't significant aswell

 

[MapleAUS]

nope.

you got it, and the muscle growth difference weren't significant aswell

If the best BBs in the world, who have every incentive to grow, take it, I think I’ll be fine haha

 

[dinfar1337]

If the best BBs in the world, who have every incentive to grow, take it, I think I’ll be fine haha

i think i've shilled berberine before just because the RISK is there but you're right. its like 0.1% difference for benefit that gives 2% difference if its even there

ok on with the day

 

[ChemBB]

Am I incorrect in saying this is only applicable to an older population?

I don't have the energy this early in the AM to write a blogpost about this, but let's add it to the "Mythbusters" series backlog.

To answer your question directly:
A skeletal muscle cell is a skeletal muscle cell.

Biological aging does not change the underlying physiology or composition of muscle fibers.

This line of thinking is the same sort of logical fallacy that gets you "women must train differently than men" because there's some perceived difference in the composition of their basic bodily tissues.

Here's the data, and biological mechanisms.

If anyone chooses to believe otherwise, that's their MO, but I've said my piece on it.

Berberine is a much better alternative.

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

genesdev.cshlp.org

> "Metformin inhibits mTOR-induced transcriptional induction of anabolism"

 

[Banana Joe]

jfl at this gatekeeping. The user in question is retarded however that doesn't negate the fact that your claims are preposterous. JFL at thinking you can put on close to 40 lbs of muscle in 2 years (implied by the not significantly higher body fat)
...
I understand you are trying to help but get off this high air of arrogance and try to provide actual helpful advice instead of misinformation and false hopes

Not sure what you are smoking, but my claims are not preposterous, and what you deem as an "air of arrogance" are simply facts.
Just because YOU don't know how to do it, doesn't mean that others can't. If you wouldn't jerk off to Zyzz and his boy band, and would have registered to just ask drug questions, you might have figured that out on your own.

Gatekeeping, LOL.