low responder to supps

[smaretick]

I'm 55 yo and have been training for ~40 yrs. I'm 5'7" ~168 lbs & ~12% bf. I train 5 or 6 days a week with free weights only.
My problem is that I seem to be a low responder to supplements. Recently, I did some tests to verify this.
For example, I recently got some MRI N30; the first couple of times I used it, I noticed that I seemed to be able to go beyond my traditional failure point in my workouts(as promised by the product). However, after using it for a couple of workouts, it seemed like my body adapted to it & it was not longer effective.
Another example: I recently got some Xyience NOX CG3 & ProPerformance Nitric Oxide Enhancer caps.
I started taking the Nitric Oxide Enhancer caps a couple of days ago.
Today I took 3 scoops of the Xyience NOX CG3 & 6 caps of the Nitric Oxide Enhancer for a total of ~7.5g of Arginine (L-Arginine, AAKG, etc) & didn't get any better of a pump than without it.
My question:
In the first example, do I need to increase the dosage of the product to keep seeing results?
In the second example am I just not responding to the NO pumps; or am I taking too much (reaching a point of diminishing returns); or do you not see effects until the Arginine level builds up in your system (I thought that arginine combines with oxygen to create NO and immediately vaso-dilation of the blood vessels occurs)?

Anyone else have similar experiences...or am I just a freak
Any ideas or theories?
Thanks in advance.

 

[Havok450]

I've notice for myself to get the good pumps from similiar products I have to get the specific muscle to burn.. similar to a burn out.. Nothing happens if I do 3 sets of 8-10 but if I do a set of 15-18 I def. get the pumped muscle group

For the vaso-dilation I believe you do have to build up took myself about 2 weeks to see results. But I have heard of these supps. not working for some.

I am taking BSN No xplode and BSN nitrix and seeing very good results from these. I have heard some negatives from xyience. But I have never used their product

 

[smaretick]

thanks...I'll try some volume training.

 

[L30]

Keep your diet in check. After that will be supplements.

 

[smaretick]

After doing a little research, I found out that a specific liver enzyme can cause some people to be unresponsive to supplements:

"Because of their genetic makeup, some people process (metabolize) drugs slowly; as a result, a drug may accumulate in the body, causing toxicity. Other people metabolize drugs so quickly that after they take a usual dose, drug levels in the blood never become high enough for the drug to be effective. Still others metabolize a drug given at the usual dose normally, but if the drug is given at a high dose or with another drug metabolized by the same enzyme system, the system may be overloaded, resulting in toxic levels of the first drug.
In about half of the people in the United States, N-acetyltransferase, a liver enzyme that metabolizes certain drugs, works slowly. In such people (called slow acetylators), drugs that are metabolized by this enzyme tend to reach higher blood levels and remain in the body longer than they do in people in whom this enzyme metabolizes drugs rapidly (fast acetylators)."

 

[jaydee]

After doing a little research, I found out that a specific liver enzyme can cause some people to be unresponsive to supplements:

"Because of their genetic makeup, some people process (metabolize) drugs slowly; as a result, a drug may accumulate in the body, causing toxicity. Other people metabolize drugs so quickly that after they take a usual dose, drug levels in the blood never become high enough for the drug to be effective. Still others metabolize a drug given at the usual dose normally, but if the drug is given at a high dose or with another drug metabolized by the same enzyme system, the system may be overloaded, resulting in toxic levels of the first drug.
In about half of the people in the United States, N-acetyltransferase, a liver enzyme that metabolizes certain drugs, works slowly. In such people (called slow acetylators), drugs that are metabolized by this enzyme tend to reach higher blood levels and remain in the body longer than they do in people in whom this enzyme metabolizes drugs rapidly (fast acetylators)."

Can I see the link for that?

I would try cycling your supplements if that is possible, even just swapping brands every now and then.

 

[smaretick]

Can I see the link for that?

I would try cycling your supplements if that is possible, even just swapping brands every now and then.

Can't seem to find the link but I remember the associated theory was related to the three groups of people in the population & how their liver processed supplements/drugs. There are 3 groups: fast and slow acetylators and then the rest of the population. Fast acetylators tend to process supplements extremely quickly; in fact so rapidly that the supplement/drug is out of their system before it has even taken effect. Slow acetylators tend to process supplements/drugs extremely slowly; in fact, so slowly that the drug tends to accumulate in their system posing a threat of overdosing.
Try doing a google search on fast and slow acetylators and you'll find a lot of extremely technical information.
Hope this helps.

 

[jaydee]

Thanks mate....will do.

 

[novicebb]

I'm 55 yo and have been training for ~40 yrs. I'm 5'7" ~168 lbs & ~12% bf. I train 5 or 6 days a week with free weights only.
My problem is that I seem to be a low responder to supplements. Recently, I did some tests to verify this.
For example, I recently got some MRI N30; the first couple of times I used it, I noticed that I seemed to be able to go beyond my traditional failure point in my workouts(as promised by the product). However, after using it for a couple of workouts, it seemed like my body adapted to it & it was not longer effective.
Another example: I recently got some Xyience NOX CG3 & ProPerformance Nitric Oxide Enhancer caps.
I started taking the Nitric Oxide Enhancer caps a couple of days ago.
Today I took 3 scoops of the Xyience NOX CG3 & 6 caps of the Nitric Oxide Enhancer for a total of ~7.5g of Arginine (L-Arginine, AAKG, etc) & didn't get any better of a pump than without it.
My question:
In the first example, do I need to increase the dosage of the product to keep seeing results?
In the second example am I just not responding to the NO pumps; or am I taking too much (reaching a point of diminishing returns); or do you not see effects until the Arginine level builds up in your system (I thought that arginine combines with oxygen to create NO and immediately vaso-dilation of the blood vessels occurs)?

Anyone else have similar experiences...or am I just a freak
Any ideas or theories?
Thanks in advance.

Personally I don't believe in taking these so called NO precursors or NO optimizers as they should be called then taking actual NO. It would be better, cheaper and more effective to get viagra, Cialis or Levitra from research supply companies then to buy these worthless products. Atleast with viagra or Cialis you know you are getting actual NO and if you want to reduce the side effects of Cialis then take half or 1/3 the dosage and get your hands on some cheap Arginine and I bet you will see better results and pumps then with those NO supplements.

If you are not willing to take that chance then you can stick with your NO products but get L-Norvaline which inhibits the arginase enzyme which might make the NO products more effective.