Dietary Supplement May Help Interrupt Growth-Promoting Signaling Pathways In Prostate Cancer Cells.
MedWire (2/22, Guy - MedWire News - Oncology - Food supplement hinders prostate cancer cell growth in low-risk patients) reported, "Australian researchers have developed a dietary supplement which interrupts growth-promoting signaling pathways in prostate cancer cells." Specifically, there was "a dose-dependent reduction in in vitro LNCaP and PC3 growth of 83 and 93%, respectively, after 72 hours of treatment with 0.64% concentration of supplement." According to the paper in the Journal of Nutrition, the "supplement is designed for men on active surveillance programs for low-risk prostate cancer and contains ingredients commonly consumed in Mediterranean and East-Asian countries where prostate cancer incidence is lower than in Western societies."
Singh J, Xie C, Yao M, et al. Food Extracts Consumed in Mediterranean Countries and East Asia Reduce Protein Concentrations of Androgen Receptor, Phospho-Protein Kinase B, and Phospho-Cytosolic Phospholipase A2{alpha} in Human Prostate Cancer Cells. J Nutr:jn.109.118745.
http://jn.nutrition.org/cgi/content/abstract/jn.109.118745v1
Active surveillance is an emerging management option for the rising number of men with low-grade, clinically localized prostate cancer. However, 30-40% of men on active surveillance will progress to high-grade disease over 5 y. With the ultimate aim of developing a food-based chemoprevention strategy to retard cancer progression in these otherwise healthy men, we have developed a blend of food extracts commonly consumed in Mediterranean countries and East Asia. The effect of the food extracts known as Blueberry Punch (BBP) on prostate cancer cell growth and key signaling pathways were examined in vitro and in vivo. BBP reduced prostate cancer cell growth in a dose-dependent manner (0.08-2.5%) at 72 h in vitro due to the reduction in cell proliferation and viability. Prostate cancer cell xenograft-bearing mice, administered 10% BBP in drinking water for 2 wk, had a 25% reduction in tumor volume compared with the control (water only). In vitro, BBP reduced protein concentrations in 3 signaling pathways necessary for the proliferation and survival of prostate cancer cells, namely androgen receptor, phospho-protein kinase B/protein kinase B, and phospho-cytosolic phospholipase A2{alpha}. The downstream effectors of these pathways, including prostate-specific antigen and glycogen synthase kinase 3{beta}, were also reduced. Thus, this palatable food supplement is a potential candidate for testing in clinical trials and may ultimately prove effective in retarding the progression of low-grade, early-stage prostate cancer in men managed by active surveillance.
MedWire (2/22, Guy - MedWire News - Oncology - Food supplement hinders prostate cancer cell growth in low-risk patients) reported, "Australian researchers have developed a dietary supplement which interrupts growth-promoting signaling pathways in prostate cancer cells." Specifically, there was "a dose-dependent reduction in in vitro LNCaP and PC3 growth of 83 and 93%, respectively, after 72 hours of treatment with 0.64% concentration of supplement." According to the paper in the Journal of Nutrition, the "supplement is designed for men on active surveillance programs for low-risk prostate cancer and contains ingredients commonly consumed in Mediterranean and East-Asian countries where prostate cancer incidence is lower than in Western societies."
Singh J, Xie C, Yao M, et al. Food Extracts Consumed in Mediterranean Countries and East Asia Reduce Protein Concentrations of Androgen Receptor, Phospho-Protein Kinase B, and Phospho-Cytosolic Phospholipase A2{alpha} in Human Prostate Cancer Cells. J Nutr:jn.109.118745.
http://jn.nutrition.org/cgi/content/abstract/jn.109.118745v1
Active surveillance is an emerging management option for the rising number of men with low-grade, clinically localized prostate cancer. However, 30-40% of men on active surveillance will progress to high-grade disease over 5 y. With the ultimate aim of developing a food-based chemoprevention strategy to retard cancer progression in these otherwise healthy men, we have developed a blend of food extracts commonly consumed in Mediterranean countries and East Asia. The effect of the food extracts known as Blueberry Punch (BBP) on prostate cancer cell growth and key signaling pathways were examined in vitro and in vivo. BBP reduced prostate cancer cell growth in a dose-dependent manner (0.08-2.5%) at 72 h in vitro due to the reduction in cell proliferation and viability. Prostate cancer cell xenograft-bearing mice, administered 10% BBP in drinking water for 2 wk, had a 25% reduction in tumor volume compared with the control (water only). In vitro, BBP reduced protein concentrations in 3 signaling pathways necessary for the proliferation and survival of prostate cancer cells, namely androgen receptor, phospho-protein kinase B/protein kinase B, and phospho-cytosolic phospholipase A2{alpha}. The downstream effectors of these pathways, including prostate-specific antigen and glycogen synthase kinase 3{beta}, were also reduced. Thus, this palatable food supplement is a potential candidate for testing in clinical trials and may ultimately prove effective in retarding the progression of low-grade, early-stage prostate cancer in men managed by active surveillance.
