Ghoul
Member
I know, I'm just saying oral Orforglipron doesn't have those requirements. I highly doubt any of these UGLs have the ability to make oral sema or tirz.
Orforglipron doesn’t have peptide issues but it still has poor solubility and low bioavailability. The excipients cost 40x what an average tablet would use.
To make a working tablet requires Spray-Dried Dispersion in a special chamber to trap molecules of the API into a polymer matrix, unusually strict local PH control in the gut using more excipients and testing, and enteric coatings or special capsules to ensure it dissolves in the right part of the digestive system. It’s very sensitive to moisture degradation. The solid tablets that meet these requirements end up being huge, 400mg for a 52mg dose.
Not many 1st tier drug makers in China have this capability, forget about UGL.
They’ll just mix the API up like every other tablet using “Generic excipient mix”, it’ll pass Jano testing as “98.9%”, and people here will say Orforglipron sucks, I guarantee it.
Remind them of this (it’s all in the Orforglipron patent) when that day comes.

