Any experiences with GC-1 (Sobetirome)?

[Proud Pangolin]

Has anyone tried it? Looks very promsing on paper. The fatloss of t3 without the catabolic and heart effect.

 

[Proud Pangolin]

Noone has tried this as a fatburner?

 

[Luke391]

I looked into it but haven't tried it yet. Seems pretty promising. I might be wrong on this but I wouldn't use it without a microdose of T4 or T3 or both since it might inhibit thyroid function?

 

[ChemBB]

Seems really interesting. Originally intended to be add-on therapy with statins for lipids + cholesterol, but also has fat-burning and insulin sensitivity effects.

https://www.tandfonline.com/doi/full/10.1517/14728222.2016.1090429

Highlights:

• “Sobetirome binds selectively to the main hepatic form of thyroid hormone receptor, TRβ1, compared to TRα1, which is principally responsible for thyrotoxic effects on heart, muscle and bone. Sobetirome also preferentially accumulates in liver, enabling stimulation of hepatic pathways that lower cholesterol without harmful side effects.”
• “Therapeutic doses of sobetirome did not elicit signs of thyrotoxicity... Notably, there were no effects on heart, markers of bone catabolism or muscle strength.”
• “Sobetirome also safely reduces body fat via induction of thermogenesis. These effects are accompanied by reduced blood glucose in mouse models of Type 2 diabetes and liver fat clearance.”
• “There is no evidence that short uses of sobetirome lead to harmful side effects and this could be useful for controlled, short-term weight loss interventions.”

Amino Asylum has it in stock with Jano tests, so does Kimera. Seems they both just got them in within the last weeks.

Will probably order some, seems like a reasonable dosage is

GC-1 (SOBETIROME) - Soma Chems

GC-1, or Sobetirome, is a selective thyroid hormone receptor β (TRβ) agonist used in research focused on lipid metabolism, cholesterol regulation, and

somachems.com

https://kimerachems.co/product/gc-1-sobetirome/

 

[Luke391]

Seems really interesting. Originally intended to be add-on therapy with statins for lipids + cholesterol, but also has fat-burning and insulin sensitivity effects.

https://www.tandfonline.com/doi/full/10.1517/14728222.2016.1090429

Highlights:

• “Sobetirome binds selectively to the main hepatic form of thyroid hormone receptor, TRβ1, compared to TRα1, which is principally responsible for thyrotoxic effects on heart, muscle and bone. Sobetirome also preferentially accumulates in liver, enabling stimulation of hepatic pathways that lower cholesterol without harmful side effects.”
• “Therapeutic doses of sobetirome did not elicit signs of thyrotoxicity... Notably, there were no effects on heart, markers of bone catabolism or muscle strength.”
• “Sobetirome also safely reduces body fat via induction of thermogenesis. These effects are accompanied by reduced blood glucose in mouse models of Type 2 diabetes and liver fat clearance.”
• “There is no evidence that short uses of sobetirome lead to harmful side effects and this could be useful for controlled, short-term weight loss interventions.”

View attachment 351059

Amino Asylum has it in stock with Jano tests, so does Kimera. Seems they both just got them in within the last weeks.

Will probably order some, seems like a reasonable dosage is

GC-1 (SOBETIROME) - Soma Chems

GC-1, or Sobetirome, is a selective thyroid hormone receptor β (TRβ) agonist used in research focused on lipid metabolism, cholesterol regulation, and

somachems.com

https://kimerachems.co/product/gc-1-sobetirome/

I think doses go from 25mcg to 100mcg a day.
Seems like it has some anti-catabolic effects in mice studies

 

[ChemBB]

Doses of up to 2.0mg produced modest fatloss in one study, 2.6mg producing 20% weight loss, and doses of ~25mg tested for toxicity threshold.

Only one study showed weight/fat loss at sub-milligram doses:
0.2 - 0.4mg daily human-equivalent dose.

The below quote does not bode well for small dose fatloss:

> "No weight loss was observed at the lower 0.4 mg/kg chow dose of sobetirome (0.08 mg/kg nominal dose)"

For a 100kg human, that'd be 0.65mg (650 mcg) a day.

"Sobetirome is known to cause dose-dependent weight loss in mice (36), and weight loss after 6 to 8 weeks of treatment was observed with the higher 2 mg/kg chow dose of sobetirome (0.4 mg/kg nominal dose) (Fig. 5). Treatment was terminated for the high-dose cohort when weight loss reached 20%, which occurred at 11 weeks for most of these mice. No weight loss was observed at the lower 0.4 mg/kg chow dose of sobetirome (0.08 mg/kg nominal dose), which allowed for 12 weeks of dosing, and a small cohort of animals was treated for an additional 6 weeks (18 weeks total) with no observed weight loss over this period "

I think I'll try 0.2mg once daily and see how that goes?
Because it's $120 to run 0.2mg x 30 days.
But honestly, I am not expecting much at that dose.

Sources:
[1]: Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine - PubMed
[2]: Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats - PubMed
[3]: A Thyroid Hormone–Based Strategy for Correcting the Biochemical Abnormality in X-Linked Adrenoleukodystrophy - PMC