Progesterone in oil

[zmurphy]

Looking for some info on progesterone in oil recipes. I've found 2 main versions
1. 100mg/ml in EO with 20?!?!?% BA (400mg of BA in 2ml yields .382ml in 2ml)
2. 50mg/ml in sesame oil with 10% BA
-Is progesterone similar to TNE in that its uniquely soluble in BA and thats why they run it so high?
-Has anyone seen any recipes different than these?
-Would adding BB help lower to BA level to something more reasonable?

This would be used for a woman's HRT so its for long term use.

 

[Superchicken]

I

Looking for some info on progesterone in oil recipes. I've found 2 main versions
1. 100mg/ml in EO with 20?!?!?% BA (400mg of BA in 2ml yields .382ml in 2ml)
2. 50mg/ml in sesame oil with 10% BA
-Is progesterone similar to TNE in that its uniquely soluble in BA and thats why they run it so high?
-Has anyone seen any recipes different than these?
-Would adding BB help lower to BA level to something more reasonable?

This would be used for a woman's HRT so it’s for long term use.

Can’t answer your questions specifically, but pip from sesame based prog injx is the #1 complaint I see in my women groups. Women end up with huge knots and bruising. Progesterone has a short half life and needs daily dosing, so it’s never ending pain. I fill my rx in a sesame base as backup, but use India pharm eo based.

 

[zmurphy]

I

Can’t answer your questions specifically, but pip from sesame based prog injx is the #1 complaint I see in my women groups. Women end up with huge knots and bruising. Progesterone has a short half life and needs daily dosing, so it’s never ending pain. I fill my rx in a sesame base as backup, but use India pharm eo based.

But you find the EO stuff to be pip free? Thats interesting, its double the concentration and seems to have even more BA in it. Thats very helpful, thanks. I know the normal dose of oral progesterone is 100-300mg per day. Can you ballpark a dose of injectable P? I'm trying to get a sense of the volume needing to be injected.

 

[bananafeet]

I've got no experience with this bro. But yeah apparently the IM with oil is horrible. Suspension is tolerated better:

Post in thread 'Perimenopause and menopause treatment options/best practices'

Jan 29, 2026

Ok I found this :
"The current study demonstrated a bioequivalence among between the test (aqueous-based progesterone formulation administered via s.c. or i.m. routes) and reference (oil-based progesterone formulation administered via i.m. route) formulations. The availability of a bioequivalent progesterone formulation in an aqueous media will provide the patients a better well tolerated alternative for their luteal phase support in the ART treatment. Progesterone is administrated for luteal phase support for 8-12 weeks of gestation in ART [7].

Progesterone oil-based injection...

• bananafeet

 

[IndividualMan]

But you find the EO stuff to be pip free? Thats interesting, its double the concentration and seems to have even more BA in it. Thats very helpful, thanks. I know the normal dose of oral progesterone is 100-300mg per day. Can you ballpark a dose of injectable P? I'm trying to get a sense of the volume needing to be injected.

just use MIGlyol 812, Cottonseed or Castor with a bit higher BA, no reason to use subpar oils. EO? why? Sesame? again, why? its not particularly good at anything.

just try 50mg/ml @7.5% BA 25% BB in castor. should hold easily. Castor is great fo any non-esterfied compounds (TrNE, TNE, E2 base, Prog, etc.)

it probably holds more than just 50mg/ml, but you can always experiment with higher mg/ml. not like progesterone is expensive.

but for christs sake, dont use sesame oil for your injectables. might as well use Olive oil from the local farmers market.

TLDR:
use castor.
pharma womens HRT oil choices are made by absolute speds using their short bus reasoning skills.

Also, always pin IM, and invest in good, sharp thin walled needles and heat the oil to at least body temp before pinning.

 

[zmurphy]

just use MIGlyol 812, Cottonseed or Castor with a bit higher BA, no reason to use subpar oils. EO? why? Sesame? again, why? its not particularly good at anything.

just try 50mg/ml @7.5% BA 25% BB in castor. should hold easily. Castor is great fo any non-esterfied compounds (TrNE, TNE, E2 base, Prog, etc.)

it probably holds more than just 50mg/ml, but you can always experiment with higher mg/ml. not like progesterone is expensive.

but for christs sake, dont use sesame oil for your injectables. might as well use Olive oil from the local farmers market.

TLDR:
use castor.
pharma womens HRT oil choices are made by absolute speds using their short bus reasoning skills.

Also, always pin IM, and invest in good, sharp thin walled needles and heat the oil to at least body temp before pinning.

Yea I'm definitely not using sesame oil. I love Test in castor oil. It would be interesting to see if castor oil raised the half life enough to go to EOD injection. If it were going into my body I'd for sure give it a try, but I'm much less willing to use a loved one as a guinea pig.

 

[Photon]

Looking for some info on progesterone in oil recipes. I've found 2 main versions
1. 100mg/ml in EO with 20?!?!?% BA (400mg of BA in 2ml yields .382ml in 2ml)
2. 50mg/ml in sesame oil with 10% BA
-Is progesterone similar to TNE in that its uniquely soluble in BA and thats why they run it so high?
-Has anyone seen any recipes different than these?
-Would adding BB help lower to BA level to something more reasonable?

This would be used for a woman's HRT so its for long term use.

I saw those pharma recipes before lol. It's actually been mentioned on this forum.

As for progesterone, I've never brewed it, but based off the compound, it doesn't seem to even need BA.

Look up Makena.

Makena is a clear, yellow, sterile, non-pyrogenic solution for intramuscular injection. Each 5 mL multidose vial contains hydroxyprogesterone caproate USP, 250 mg/mL (25% w/v), in castor oil USP (28.6% v/v) and benzyl benzoate USP (46% v/v) with the preservative benzyl alcohol NF (2% v/v).

Oh hey, that's the same formula as nebido.
I'd brew using the same formula with 15% less BB and more castor/mix with MCT.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021945s005lbl.pdf

 

[LGOP528]

I just got progesterone in and was going back and forth with ChatGPT over the carrier oil. I just want to state I don’t fully trust it so I am not sure what I am going to do but apparently pure castor oil is not a good carrier oil for progesterone because of how it is used. There is no ester attached to the progesterone so the rate of release is solely based on the oil and solvent combo. This could be a reason that BB isn’t used in pharma. If it releases too quickly it can cause issues and too slowly will leave it in the system longer than wanted. My wife is cycling it so this would be a problem. I also like the MCT/castor oil mix and I know it helps with pip. I am ok experimenting on myself but my wife might not be as receptive to it. lol

 

[bananafeet]

Guys this was a prick to get a source for:

Source: ANNEX 1. Chemical and physical data and information on production and use for oestrogens and progestogens used in oral contraceptives, progestogen-only contraceptives and post-menopausal hormonal therapy - Hormonal Contraception and Post-menopausal Hormonal Therapy - NCBI Bookshelf

Basically it's not soluble in veggie oils. Make a suspension. I've linked an article to how it's more tolerable in a previous post

 

[LGOP528]

I saw those pharma recipes before lol. It's actually been mentioned on this forum.

As for progesterone, I've never brewed it, but based off the compound, it doesn't seem to even need BA.

Look up Makena.

Makena is a clear, yellow, sterile, non-pyrogenic solution for intramuscular injection. Each 5 mL multidose vial contains hydroxyprogesterone caproate USP, 250 mg/mL (25% w/v), in castor oil USP (28.6% v/v) and benzyl benzoate USP (46% v/v) with the preservative benzyl alcohol NF (2% v/v).

Oh hey, that's the same formula as nebido.
I'd brew using the same formula with 15% less BB and more castor/mix with MCT.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021945s005lbl.pdf

hydroxyprogesterone caproate Is not the formulation for HRT. I haven’t seen any pharma recipes that have BB in it.

 

[Photon]

hydroxyprogesterone caproate Is not the formulation for HRT. I haven’t seen any pharma recipes that have BB in it.

It's not, its derived from progesterone which is the closest i could find that was used for pharma.

Guys this was a prick to get a source for:

Source: ANNEX 1. Chemical and physical data and information on production and use for oestrogens and progestogens used in oral contraceptives, progestogen-only contraceptives and post-menopausal hormonal therapy - Hormonal Contraception and Post-menopausal Hormonal Therapy - NCBI Bookshelf

Basically it's not soluble in veggie oils. Make a suspension. I've linked an article to how it's more tolerable in a previous post

It wasn't tested with BB.
it'll dissolve.

A Progesterone Microneedle Patch for Self-Administration in the Prevention of Preterm Birth in a Mouse Model - PMC

Progesterone, recommended for preventing preterm birth (PTB) in high-risk women, is traditionally administered via oral capsules, vaginal gels, and oil injections, which pose issues like low bioavailability, systemic side effects, and irritation, ...

pmc.ncbi.nlm.nih.gov

 

[Photon]

WO2021179817A1 - Progesterone emulsion injection and preparation method therefor - Google Patents

Disclosed is a progesterone emulsion injection, comprising progesterone, a grease solvent and water for injection, wherein the grease solvent is a mixture of oil for injection and benzyl benzoate, and the mass ratio of the oil for injection to the benzyl benzoate is 1:5-5:1. The progesterone in...

patents.google.com

The oil is basically useless, everything is done by BB lol.
I guess @bananafeet is right.

 

[bananafeet]

WO2021179817A1 - Progesterone emulsion injection and preparation method therefor - Google Patents

Disclosed is a progesterone emulsion injection, comprising progesterone, a grease solvent and water for injection, wherein the grease solvent is a mixture of oil for injection and benzyl benzoate, and the mass ratio of the oil for injection to the benzyl benzoate is 1:5-5:1. The progesterone in...

patents.google.com

The oil is basically useless, everything is done by BB lol.
I guess @bananafeet is right.

View attachment 378395

I think you can dissolve a bit in Arachis oil/EO. I can't do the math but it's 1 in 60.

You don't need much progesterone for TRT so I don't see an issue with 25mg/ml or 50mg/ml.

I'm not a chemist but I think it's shit to dissolve because it's the master hormone like the one at the top of the chain closer to cholesterol so it's got no where to bind to another oil or water. And it doesn't have an ester. Which makes it worse.

Sorry I don't have sources but I was looking into it a while ago.

In women the sudden drop in progesterone post partum and it's metabolite allopregnenalone is implicated in post partum depression and in PMDD.

If they could find a reliable delivery mechanism for these two hormones they would save so many lives. I'm sure they are trying.


The other option is the suspensions:

 

[Photon]

I think you can dissolve a bit in Arachis oil/EO. I can't do the math but it's 1 in 60.

You don't need much progesterone for TRT so I don't see an issue with 25mg/ml or 50mg/ml.

I'm not a chemist but I think it's shit to dissolve because it's the master hormone like the one at the top of the chain closer to cholesterol so it's got no where to bind to another oil or water. And it doesn't have an ester. Which makes it worse.

Sorry I don't have sources but I was looking into it a while ago.

In women the sudden drop in progesterone post partum and it's metabolite allopregnenalone is implicated in post partum depression and in PMDD.

If they could find a reliable delivery mechanism for these two hormones they would save so many lives. I'm sure they are trying.

View attachment 378398
The other option is the suspensions:

View attachment 378397

1g/60ml=~16mg/ml

In the above patent it writes MCT alone is 32.8mg/ml.
if you mix with EO it'll probably hit 50 easily.

 

[zmurphy]

Guys this was a prick to get a source for:
View attachment 378387
Source: ANNEX 1. Chemical and physical data and information on production and use for oestrogens and progestogens used in oral contraceptives, progestogen-only contraceptives and post-menopausal hormonal therapy - Hormonal Contraception and Post-menopausal Hormonal Therapy - NCBI Bookshelf

Basically it's not soluble in veggie oils. Make a suspension. I've linked an article to how it's more tolerable in a previous post

Well that explains why they run the BA so high. 1 to 8 solubility vs 1 to 60 in EO.

 

[LGOP528]

Here is Pharma doing 10% BA in sesame seed oil

 

[bananafeet]

Well that explains why they run the BA so high. 1 to 8 solubility vs 1 to 60 in EO.

Also explains why the suspension was more tolerable. I've got castor oil based testosterone enanthate in the cupboard. It's real pharma stuff I got prescribed but I refuse to use it. PIPs like a mofo because it's super high in BB.

Progesterone doesn't have an ester so what's the dosing protocol for HRT? Daily dosing during the luteal phase?

No wonder why compliance is so poor.

 

[LGOP528]

Also explains why the suspension was more tolerable. I've got castor oil based testosterone enanthate in the cupboard. It's real pharma stuff I got prescribed but I refuse to use it. PIPs like a mofo because it's super high in BB.

Progesterone doesn't have an ester so what's the dosing protocol for HRT? Daily dosing during the luteal phase?

No wonder why compliance is so poor.

Absorption: After intramuscular administration of 10 mg of progesterone in oil, maximum plasma concentrations (geometric mean of 7 ng/mL) were reached withinapproximately 8 hours after injection and plasma concentrations remained above baseline for about 24 hours after injection. Injection of 10, 25, and 50 mg resulted in geometric mean values for maximum plasma concentration (C MAX
) of 7, 28, and 50 ng/mL, respectively.

PROGESTERONE INJECTION, USP IN SESAME OIL - FOR INTRAMUSCULAR USE ONLYRx only

DOSAGE AND ADMINISTRATION​

Progesterone Injection, USP is administered by intramuscular injection. It differs from other commonly used steroids in that it is irritating at the place of injection.

Amenorrhea: Five to 10 mg are given for six to eight consecutive days. If there has been sufficient ovarian activity to produce a proliferative endometrium, one can expect withdrawal bleeding forty-eight to seventy-two hours after the last injection. This may be followed by spontaneous normal cycles.

Functional Uterine Bleeding: Five to 10 mg are given daily for six doses. Bleeding may be expected to cease within six days. When estrogen is given as well, the administration of progesterone is begun after two weeks of estrogen therapy. If menstrual flow begins during the course of injections of progesterone, they are discontinued.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever the solution and container permit.

 

[Superchicken]

But you find the EO stuff to be pip free? Thats interesting, it’s double the concentration and seems to have even more BA in it. Thats very helpful, thanks. I know the normal dose of oral progesterone is 100-300mg per day. Can you ballpark a dose of injectable P? I'm trying to get a sense of the volume needing to be injected.

Zero pip for me, likely because the volume is so low. The formula I have is 100mg/ml, and I use 8mg daily. (Rx was higher volume because of a weaker strength of 50mg/ml.) A few times I’ve dosed 25mg without issue to stop mid cycle spotting after missing a dose.

Before being prescribed inj, my oral dose was 300mg, and prescribed dose inj dose is 15mg nightly. That was with estradiol cyp at 2mg/wk.

I’m currently at e cyp 3mg a week and the 8mg progest. It was trial and error finding what worked best; dropped it down to lowest possible to where bleeding was controlled without cycle suppression.

I know people have diff experiences with eo, but my HSCRP has been <0.2mg/l for years, and remains unchanged. If it ever becomes a problem I’d look into the suspension bananafeet mentioned.

 

[IndividualMan]

Zero pip for me, likely because the volume is so low. The formula I have is 100mg/ml, and I use 8mg daily. (Rx was higher volume because of a weaker strength of 50mg/ml.) A few times I’ve dosed 25mg without issue to stop mid cycle spotting after missing a dose.

Before being prescribed inj, my oral dose was 300mg, and prescribed dose inj dose is 15mg nightly. That was with estradiol cyp at 2mg/wk.

I’m currently at e cyp 3mg a week and the 8mg progest. It was trial and error finding what worked best; dropped it down to lowest possible to where bleeding was controlled without cycle suppression.

I know people have diff experiences with eo, but my HSCRP has been <0.2mg/l for years, and remains unchanged. If it ever becomes a problem I’d look into the suspension bananafeet mentioned.

great to know.