MESO-Rx Exclusive Cardarine (GW501516)

[MESO-Rx Administrator]

MESO-Rx has a new original article on Cardarine (GW501516) written by @PeterBond :

"To date, however, there’s not a single approved drug that selectively acts on PPARδ. That’s not to say that the pharmaceutical industry hasn’t been interested in this receptor subtype: a tremendous amount of research has been done in this area. In this article I will focus on a candidate drug that acts on this receptor and made it into clinical trials: cardarine (GW501516). While the clinical trials showed promising results, two rodent studies that screened for carcinogenicity of the compound casted a dark shadow on it."

The Rise and Fall of Cardarine (GW501516)

Estimated reading time: 12 minutes Table of contentsIntroductionCardarine (GW501516) is a PPARδ agonist developed by GlaxoSmithKline (GSK)Cardarine

thinksteroids.com

 

[rbc]

Cararine works for endurance, no question, but it just doesn't make sense for most athletes. It doesn't cause any additional weight loss as such (extra cardio obviously will, so it is indirect). As many have noted, it stalls or suppresses high end power. You will basically become an unstoppable diesel engine, but no high end the way manipulating phlebotomy will give you. And it's indisputably mutagenic as an inherent property of the substance and almost certainly carcinogenic. I got lucky in that I got numerous benign skin tags (from periodic low dose administration), but not cancer. It's so tempting since its a simple pill, but just don't do it - less effective than ITTP or injectable SR9009 or injectable carnatine, and far less effective than any mechanism that raises RBC in a controlled way.

 

[khardet8]

Cararine works for endurance, no question, but it just doesn't make sense for most athletes. It doesn't cause any additional weight loss as such (extra cardio obviously will, so it is indirect). As many have noted, it stalls or suppresses high end power. You will basically become an unstoppable diesel engine, but no high end the way manipulating phlebotomy will give you. And it's indisputably mutagenic as an inherent property of the substance and almost certainly carcinogenic. I got lucky in that I got numerous benign skin tags (from periodic low dose administration), but not cancer. It's so tempting since its a simple pill, but just don't do it - less effective than ITTP or injectable SR9009 or injectable carnatine, and far less effective than any mechanism that raises RBC in a controlled way.

Do you mean itpp I never heard of ittp??

 

[rbc]

Do you mean itpp I never heard of ittp??

Yes, typo

 

[AllGoodThings]

Cararine works for endurance, no question, but it just doesn't make sense for most athletes. It doesn't cause any additional weight loss as such (extra cardio obviously will, so it is indirect). As many have noted, it stalls or suppresses high end power. You will basically become an unstoppable diesel engine, but no high end the way manipulating phlebotomy will give you. And it's indisputably mutagenic as an inherent property of the substance and almost certainly carcinogenic. I got lucky in that I got numerous benign skin tags (from periodic low dose administration), but not cancer. It's so tempting since its a simple pill, but just don't do it - less effective than ITTP or injectable SR9009 or injectable carnatine, and far less effective than any mechanism that raises RBC in a controlled way.

This was my experience. I took 10mg a day, and within a matter of weeks (can't remember exact time frame, but definitely less than a month) I had a significant boost in my cardio, but also a very noticeable reduction in my strength. It was especially noticeable with larger body parts. I remember the first time I noticed it was on leg extensions. Its as of my cns wasn't working correctly. I was telling my legs to extend, didn't feel fatigued, but the muscle contractions just didn't have the same power, and the feel of that mind muscle connection was missing something. All my lifts suffered, and I was constantly flat. Couldn't get a pump no matter what I did. Terrible experience. The claim that it converts fast twitch fibers to slow twitch makes a lot of sense when I think about my experience with it.

 

[cajunpauper]

This comes down to acceptable, or not acceptable risk.

Personally, I’ll be relocating my cardarine to the waste bin.

 

[EXCELLENTMENTALHEALTH]

I hear a lot of people have good results with 20mg, what about higher doses?

Was planning to run it 4 weeks leading up to a BJJ tournament. I'm 230lbs so figured I am probably on the heavier side.

 

[khardet8]

I hear a lot of people have good results with 20mg, what about higher doses?

Was planning to run it 4 weeks leading up to a BJJ tournament. I'm 230lbs so figured I am probably on the heavier side.

Honestly for me I could say it lowered my libido and I lost strength while on it however I lost weight

 

[khardet8]

Honestly for me I could say it lowered my libido and I lost strength while on it however I lost weight

On the good note all the other negative effects when I stopped taking it they went away after 2 weeks so if you take it and experience the same thing just simply stop taking it...

 

[EXCELLENTMENTALHEALTH]

Did it improve your cardio or endurance?

 

[khardet8]

Maybe a little however weight loss was crazy also I reccomend 10 mg if you take 20 mg or more it may be too much but you will feel overwhelmed by it and you will want to cut down...I heard good things about stenbolic sr 9009 I am going to try that soon ill let you know what that does combined w test e and anavar im starting in a week

 

[EXCELLENTMENTALHEALTH]

Well I weigh ~220lbs so might need more on the heavier side. I'm just loking for the cardio benefits.

I have a martial arts tournament coming up so was tihnking of like 500test/350eq/20mgcardanine stack for it for 4 weeks.

 

[Avarice911]

Cardarine is one of those drugs that is kinda just there in the background but I don't really feel it in any negative way. Endurance is def improved immediately with it on just 10mg. Clen + gw + test/gh/var gets you shredded nicely if diet is on point and you shouldnt feel any negatives with the right doses

 

[EXCELLENTMENTALHEALTH]

The focus is 100% on cardio and endurance. I would obviously like to keep my strength gains made on a 350tren cycle I just dropped as much as possible, and I'm doing a slight cut.

Don't know much about clen, don't think var will help with my cardio and I'd rather take injectables than orals.

I was wondering if there's a benefit to running 8 weeks vs just like 4 weeks if it kicks in so quickly. Is it going to have better cardio improvement from running it longer, or is it just like 'well you're saturated ~week in and that's that'

I mean the longer you run tren the better and better it is you know, so I dunno.

 

[khardet8]

The focus is 100% on cardio and endurance. I would obviously like to keep my strength gains made on a 350tren cycle I just dropped as much as possible, and I'm doing a slight cut.

Don't know much about clen, don't think var will help with my cardio and I'd rather take injectables than orals.

I was wondering if there's a benefit to running 8 weeks vs just like 4 weeks if it kicks in so quickly. Is it going to have better cardio improvement from running it longer, or is it just like 'well you're saturated ~week in and that's that'

I mean the longer you run tren the better and better it is you know, so I dunno.

To keep it simple brother I hope the carabiner isn't detrimental to your performance at the tournament..I think other sarms like ostarine and rad would help but they burn fat I know you are focused on muscle endurance...honestly for me and this is only for me the cardarine lowered my strength and muscle endurance and libido..I am only sharing my experience and I want you to win your tournament

 

[EXCELLENTMENTALHEALTH]

To keep it simple brother I hope the carabiner isn't detrimental to your performance at the tournament..I think other sarms like ostarine and rad would help but they burn fat I know you are focused on muscle endurance...honestly for me and this is only for me the cardarine lowered my strength and muscle endurance and libido..I am only sharing my experience and I want you to win your tournament

It sounds like your experience is different than everyone else's?

 

[Avarice911]

It sounds like your experience is different than everyone else's?

Completely opposite of my experience lol

 

[Vrjorp]

Helps that little extra push at the end of sets

 

[AlbanVautier]

I ve read that if you are running it long term it is inflammatory?

 

[heelhook47]

Been running 10mg pre-training (grappling) for 5/6 weeks now; Up to 2x per day (20mg max daily dose)

Noticeable improvement in terms of ability to output the same pace throughout my rounds; effect was almost immediately notable (within 1/2 doses)

In terms of lifting; I did notice maybe 1 extra rep on hypertrophy sets, along with ever so slightly lower perceived RPE - Nothing crazy.

Unsure of effects on fat burning as I’m already in a deficit and taking other compounds.

Overall; It works, but I’d ideally look for another compound that can produce the same effect without the worry of ingesting a carcinogen daily for prolonged periods.

But hey, I smoke every day and eat BBQ; so maybe that’ll kill me before the Cardarine does!

 

[khardet8]

What else are you taking for burning fat