HGH secretagogues

[anabullic]

hello Meso I have been doing some research lately on HGH secretagogues specificially looking to CJC-1295/IPA without DAC and tesamorelin.
Does anyone have any experience/thoughts on these (or others i haven't mentioned) that they'd like to share?
thanks-
anabullic

 

[Ghoul]

hello Meso I have been doing some research lately on HGH secretagogues specificially looking to CJC-1295/IPA without DAC and tesamorelin.
Does anyone have any experience/thoughts on these (or others i haven't mentioned) that they'd like to share?
thanks-
anabullic

How old are you?

What effects are most important to you?

 

[anabullic]

How old are you?

What effects are most important to you?

28
most importantly I'd like to see it's effects on my sleep and recovery.

my IGF levels have declined a bit over the last year

 

[keepbashing]

Another question for you: why do you prefer HGH secretagogues over HGH itself?
Don’t get me wrong, at 28, you can most likely benefit from them. I just want to understand your reasoning so we can give advice that actually fits you.

 

[anabullic]

Another question for you: why do you prefer HGH secretagogues over HGH itself?
Don’t get me wrong, at 28, you can most likely benefit from them. I just want to understand your reasoning so we can give advice that actually fits you.

i feel like it is a good 'intro' to potentially using HGH later on. but would rather see if I could get enough benefit from the secretagogues

 

[keepbashing]

Due to the short half-life, my suggestion for CJC/IPA would be at least two, preferably three injections per day. Since this protocol only stimulates the release of already existing GH, a sufficiently long fasting period before the injection (at least 3 hours) and 30–60 minutes afterward is important. The last injection should be taken right before bed, and the first one in the morning while fasted.

In my opinion, starting with 100 mcg CJC + 100 mcg Ipamorelin per injection is perfectly fine. You can titrate up to 300 mcg each, but studies have shown that there’s no significant additional increase in GH release beyond that point.

Not sure how familiar you are with this topic, though.

Oh and if you got any labs post them. You were talking about decreasing IGF1.

 

[anabullic]

Due to the short half-life, my suggestion for CJC/IPA would be at least two, preferably three injections per day. Since this protocol only stimulates the release of already existing GH, a sufficiently long fasting period before the injection (at least 3 hours) and 30–60 minutes afterward is important. The last injection should be taken right before bed, and the first one in the morning while fasted.

In my opinion, starting with 100 mcg CJC + 100 mcg Ipamorelin per injection is perfectly fine. You can titrate up to 300 mcg each, but studies have shown that there’s no significant additional increase in GH release beyond that point.

Not sure how familiar you are with this topic, though.

Oh and if you got any labs post them. You were talking about decreasing IGF1.

IGF 1 was 225 may of 2024. last time I had checked it was 164 August 2025

 

[anabullic]

Due to the short half-life, my suggestion for CJC/IPA would be at least two, preferably three injections per day. Since this protocol only stimulates the release of already existing GH, a sufficiently long fasting period before the injection (at least 3 hours) and 30–60 minutes afterward is important. The last injection should be taken right before bed, and the first one in the morning while fasted.

In my opinion, starting with 100 mcg CJC + 100 mcg Ipamorelin per injection is perfectly fine. You can titrate up to 300 mcg each, but studies have shown that there’s no significant additional increase in GH release beyond that point.

Not sure how familiar you are with this topic, though.

Oh and if you got any labs post them. You were talking about decreasing IGF1.

the 3 injections per day does not sound ideal

 

[keepbashing]

the 3 injections per day does not sound ideal

Then the only thing left for you is HGH. Wouldn't go below 2 (preferable 3) injections per day on secretagogues.

 

[anabullic]

Then the only thing left for you is HGH. Wouldn't go below 2 (preferable 3) injections per day on secretagogues.

i appreciate your input

 

[keepbashing]

You are welcome.
If in doubt, try CJC/IPA, and if the fasting periods and multiple injections per day aren’t feasible for you, you can switch to HGH.

 

[ParquetPatquet]

Tesamorelin actually has phase 3 clinical trial data behind it for what it's trying to do. That's better and more extensive than all of the other secretagogues. I would start there. 2mg once a day is the standard dosage. You should check your levels again after 4 to 6 weeks ti assess how you're responding to it, you might find that you can lower yoir dose.

 

[keepbashing]

Tesamorelin half life is around 30 minutes. Once a day will not be enough.
Thats said there is a reason why a longer half-life is not desired for this class of compounds. The keyword is HGH bleeding. HGH is released in waves. Unlike HGH, IPA/CJC Tesamorelin depend on sufficient HGH being present in the pituitary. HGH exerts its effects more effectively in high-amplitude pulses than with continuous release at a significantly lower level. That is why CJC-DAC is preferably avoided.

However, since we want to amplify more than one pulse, the frequency of injections becomes relevant again for the desired application.

 

[keepbashing]

Tesamorelin actually has phase 3 clinical trial data behind it for what it's trying to do. That's better and more extensive than all of the other secretagogues. I would start there. 2mg once a day is the standard dosage. You should check your levels again after 4 to 6 weeks ti assess how you're responding to it, you might find that you can lower yoir dose.

Moreover, the study you are referring to focuses on fat gain or fat loss in HIV patients, and is not really applicable to the clientele considering the use of these compounds in this context.

 

[ParquetPatquet]

Tesamorelin half life is around 30 minutes. Once a day will not be enough.
Thats said there is a reason why a longer half-life is not desired for this class of compounds. The keyword is HGH bleeding. HGH is released in waves. Unlike HGH, IPA/CJC Tesamorelin depend on sufficient HGH being present in the pituitary. HGH exerts its effects more effectively in high-amplitude pulses than with continuous release at a significantly lower level. That is why CJC-DAC is preferably avoided.

However, since we want to amplify more than one pulse, the frequency of injections becomes relevant again for the desired application.

So it's the frequency we're more worried about, got it . You said a minimum of 2 daily injections. Would you do one before bed (fasted) , and one first thing in the morning then?

 

[keepbashing]

Exactly. Each injection should be taken while fasted, followed by a fasting period of 30–60 minutes afterward. A third injection can be usefully added after a (fasted) training session.

 

[Photon]

hello Meso I have been doing some research lately on HGH secretagogues specificially looking to CJC-1295/IPA without DAC and tesamorelin.
Does anyone have any experience/thoughts on these (or others i haven't mentioned) that they'd like to share?
thanks-
anabullic

I'm actually starting my first run of tesa. Moving over from hgh, planning to run for 6m with high doses reta before moving back to hgh.

Read below.

S

Thread 'Loving my first go at tesamorelin'

Jul 10, 2025

Been using gear for over 30 years and recently cut back on my dosages of AAS and have tried a few different peptides. I really think Tesamorelin might be a gem. I’ve been running just 1mg per day and and have definitely noticed visible visceral fat loss after about 25 days so far. I’m also using MT2 which I believe also has some fat burning effect- but there are definitely some nice results happening. I’ve struggled with “roid gut” for years and for anyone also with this issue-
1. Cut test to 300mg/week . I also run primo at 400mg
2. Try tesamorelin

Not sure who else has roid gut but am...

• Slicknyc
• Replies: 148
• Forum: Human Growth Hormone and Peptides

• 

 

[Infernalmango]

Images left to right: baseline, 4iu hgh, 2mg tesamorelin and 400mcg ipamorelin. Both gh and tesa/ipa were or are taken in one shot before bed. I actually had bought tesa/ipa, cjc/ipa, and hgh at the same time. Ended up starting with hgh and ran it for ~6months. Loved it. Definitely slept better with it compared to tesa/ipa which Iv now been running for ~2 months. Haven’t tried the cjc yet.

 

[heavydutygorilla]

Images left to right: baseline, 4iu hgh, 2mg tesamorelin and 400mcg ipamorelin. Both gh and tesa/ipa were or are taken in one shot before bed. I actually had bought tesa/ipa, cjc/ipa, and hgh at the same time. Ended up starting with hgh and ran it for ~6months. Loved it. Definitely slept better with it compared to tesa/ipa which Iv now been running for ~2 months. Haven’t tried the cjc yet.

Thanks for sharing these bloodwork results man! Definitely a good insight into the difference between the gh and the secretagogues. Did you run it in this fashion to recover natural production after coming off of gh?

 

[Infernalmango]

Thanks for sharing these bloodwork results man! Definitely a good insight into the difference between the gh and the secretagogues. Did you run it in this fashion to recover natural production after coming off of gh?

To be honest it was mostly to burn up inventory. I waited a week or 2 after stopping gh before starting the secretagogues to make sure any results were as true to the tesa combo as possible.

I have a big surgery coming up in January so I’m kind of just cruising until then, and I’d rather save the gh for when I’m pushing things hard. Once I’m through the tesa/ipa and cjc/ipa I’ll start gh again and probably won’t go back to the secretagogues.