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My Reta dose creeping higher

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Testshopper

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Ok. First real post so be gentle

I’ve been on Reta since May, and recently I’ve felt like the appetite suppression is more or less gone. My hunger is back to where I started it feels like. I started out with 1mg/week a while back, which had great effects. These days I’m running 1mg ED, but I’m quite hungry. I’m recomping, which is OK, but I’m thinking maybe I should add another glp-1, add cagri, do a complete reset or even up the dose to 1.5mg ED (over a couple of weeks).

When I have increased recently, it feels like I’m getting hungrier actually. Weird right?

My goal is to get pretty shredded, as much as possible before vacation in January, and keep muscle. I’m on enough juice to not lose in a deficit and I’m doing a PPL approximately 5-6 times pr week. I’m around 10-12% BF now, the leanest I have ever been.

Open for suggestions.

Macros:

250-300g protein
50-80g fat
Varying carbs from day to day, but 250-450g
 
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Ah, yes I am. Same kit as I have used and I still get some side effects when I increase. I still fart and burp all the time if I eat more than small meals. I’m as sure as one can be I guess.
 
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Idk if it will make a difference, but maybe try 2.5 mg every other day. I wasn’t a fan of daily I ended up at 3.5 mg every other day hit my goal but the skin sensitivity at that dose was getting to be alot idk how much longer I would’ve felt like dealing with it. For some people the higher bolus dose is better for appetite suppression.
 
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Right. My friend has been trying to make that point, I would hate to make him right

I have quite sensitive skin as well. I’ve been hearing talk about that on podcasts. It’s not bothering me too much though.

I’ll give 2mg EOD a go, seems like the easiest thing to try.
 
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This has happened to me before. Your body metabolically adapts to the compound. When I get to where a 1mg daily dose produces a not so stellar response, I take a break for about 3 to 4 weeks and run Cagrilintide during this time to aid in appetite suppression. Best of luck
 
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I added the cagri in for more suppression instead of upping my dose. I'm currently at 3mg weekly (pin 1mg m/w/f) of reta, I add in 250mcg of cagri on thursday to help keep the appetite down over the weekend. It's been working great for me!
 
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Moetizzle said:
This has happened to me before. Your body metabolically adapts to the compound. When I get to where a 1mg daily dose produces a not so stellar response, I take a break for about 3 to 4 weeks and run Cagrilintide during this time to aid in appetite suppression. Best of luck
Click to expand...
So what happens when you go off? Eat everything in sight or what?
 
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So, you're pretty lean already and been on Reta for a while doing the split/micro protocol. It seems like you're depending on the reta for appetite suppression, which is one of its effects, but maybe not its strongest. I have read into cagri small dosing as an option, then others have toyed around with using a second GLP1 like tirz. Also, you're current macros tell me you're around 2,450cals. I'm wondering if changing those macros around a little bit will help you cut a little more? Reduce fats from 18-19% to ~12%ish? Increase protein or carbs based on your weight? But making sure it doesn't kill your energy/etc.

Personally, i've been focused on weight loss and am a bit larger than you. Been on Reta the last 2 months and am now on 8mg/week, which i take in one administration. But, I've used brandname Sema and Tirz, both of which has much stronger appetite suppression than Reta across all titrations, but caused significant GI issues for me as I reached higher titrations. Reta has been solid at keeping me satiated and removing food noise without killing my joy of some foods. Nevertheless, I have noticed less appetite suppression as I increased to 8mg and I'm considering a world where I add in something like cagri or a little tirz. If i do, then i'll let you know how it goes. I'll probably first go through the next 3 weeks with 8mg, then see if 12mg makes a difference, so that may be a bit.

I would be curious about whether or not you taking a single pin of 4-8mg weekly might help bolster the appetite suppression and satiety for you. I would assume this would get your overall baseline level of reta in the system a little higher than the split dosing but you'd be at that peak less often. Nevertheless, not sure if this would make a huge diff.
 
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DazDillinger said:
Idk if it will make a difference, but maybe try 2.5 mg every other day. I wasn’t a fan of daily I ended up at 3.5 mg every other day hit my goal but the skin sensitivity at that dose was getting to be alot idk how much longer I would’ve felt like dealing with it. For some people the higher bolus dose is better for appetite suppression.
Click to expand...

ChokeHldCharlie said:
Just follow the protocol. I haven't heard of great results micro dosing it. It also takes about 3-4 weeks to be at peak levels to be in your system at a set mg/week. I would personally go back to once every 5-7 days and titrate up until you get the desired effects you want.
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Would agree with what these guys have said - I don't see a huge advantage to the microdosing approach and it might even be counter-productive. Twice per week should be ok, maybe three times if you are taking over 8 mg.

You prob already know this since you've been on it for so long, but be sure to give each dosage a good 4 weeks before titrating upward. I had been on Tirz before Reta, and with both compounds I noticed that the impact of the appetite suppression of each successive dosage was not really felt until 2 weeks in. When I tried to ramp the reta from 2 to 3 after 2 weeks, I got way too much appetite suppression and heartburn / GI discomfort.

I've seen some posts / vids / pods from guys on reta for 12 - 18 months, they have taken 4 week breaks and re-started. Some used cagri in between, some didn't. When I get to that point I plan to not use anything to see how it feels off of the compound entirely (and also to rebound up since even at 240+ lbs I can't seem to eat more than 3000 calories no matter how hard I try).
 
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assielima said:
So, you're pretty lean already and been on Reta for a while doing the split/micro protocol. It seems like you're depending on the reta for appetite suppression, which is one of its effects, but maybe not its strongest. I have read into cagri small dosing as an option, then others have toyed around with using a second GLP1 like tirz. Also, you're current macros tell me you're around 2,450cals. I'm wondering if changing those macros around a little bit will help you cut a little more? Reduce fats from 18-19% to ~12%ish? Increase protein or carbs based on your weight? But making sure it doesn't kill your energy/etc.

Personally, i've been focused on weight loss and am a bit larger than you. Been on Reta the last 2 months and am now on 8mg/week, which i take in one administration. But, I've used brandname Sema and Tirz, both of which has much stronger appetite suppression than Reta across all titrations, but caused significant GI issues for me as I reached higher titrations. Reta has been solid at keeping me satiated and removing food noise without killing my joy of some foods. Nevertheless, I have noticed less appetite suppression as I increased to 8mg and I'm considering a world where I add in something like cagri or a little tirz. If i do, then i'll let you know how it goes. I'll probably first go through the next 3 weeks with 8mg, then see if 12mg makes a difference, so that may be a bit.

I would be curious about whether or not you taking a single pin of 4-8mg weekly might help bolster the appetite suppression and satiety for you. I would assume this would get your overall baseline level of reta in the system a little higher than the split dosing but you'd be at that peak less often. Nevertheless, not sure if this would make a huge diff.
Click to expand...
Cool, looking forward to seeing how it goes
 
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I’ve been taking Retatrutide for 10 weeks now — started at 1 mg and currently at 3.5 mg per week.
I’ve had the best experience with daily (ED) dosing, as it keeps the appetite suppression steady without noticeable highs or lows.


I’ll stay on Retatrutide until I reach about 5 mg per week, which should give me roughly a 20-week total Retatrutide cycle.
After a short break, I plan to try Cagrilintide next.


Has anyone here followed a similar approach?
What would be a good starting dose to balance lethargy and appetite control?
 
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Testshopper said:
Ok. First real post so be gentle

I’ve been on Reta since May, and recently I’ve felt like the appetite suppression is more or less gone. My hunger is back to where I started it feels like. I started out with 1mg/week a while back, which had great effects. These days I’m running 1mg ED, but I’m quite hungry. I’m recomping, which is OK, but I’m thinking maybe I should add another glp-1, add cagri, do a complete reset or even up the dose to 1.5mg ED (over a couple of weeks).

When I have increased recently, it feels like I’m getting hungrier actually. Weird right?

My goal is to get pretty shredded, as much as possible before vacation in January, and keep muscle. I’m on enough juice to not lose in a deficit and I’m doing a PPL approximately 5-6 times pr week. I’m around 10-12% BF now, the leanest I have ever been.

Open for suggestions.

Macros:

250-300g protein
50-80g fat
Varying carbs from day to day, but 250-450g
Click to expand...
Semaglutide will nuke your appetite more than anything else (the nausea is a feature, not a bug imo). I've also seen people say that less frequent dosing lowers appetite more than ED injections. Reta is also notorious for being a poor appetite suppressant compared to the others.

You're super lean though. Appetite is going to be high no matter what, especially being on steroids. GLPs set your hunger to maintain a certain weight: once you drop below that threshold, appetite is going to increase, to return to that homeostasis.

You look great though and are already shredded to literally everybody but yourself. Not sure how steep your deficit is, but it doesn't look like you have too much fat to lose, and you have plenty of time to do it.
 
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rxzed said:
GLPs set your hunger to maintain a certain weight: once you drop below that threshold, appetite is going to increase, to return to that homeostasis.
Click to expand...

This is how all GLPs work, yet so few understand this and think they lose effectiveness like diet pills.

On pharma, people who reach their goal weight stay on a maintenance dose and experience no sides or appetite suppression, unless they somehow put in a few pounds, then suppression returns.

If GLP meds (hormones actually), “lost effectiveness”, people using them would gradually regain weight and need perpetual dose increases to stay stable. That doesn’t happen, even after years of using the same dose.
 
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Testshopper said:
Ok. First real post so be gentle

I’ve been on Reta since May, and recently I’ve felt like the appetite suppression is more or less gone. My hunger is back to where I started it feels like. I started out with 1mg/week a while back, which had great effects. These days I’m running 1mg ED, but I’m quite hungry. I’m recomping, which is OK, but I’m thinking maybe I should add another glp-1, add cagri, do a complete reset or even up the dose to 1.5mg ED (over a couple of weeks).

When I have increased recently, it feels like I’m getting hungrier actually. Weird right?

My goal is to get pretty shredded, as much as possible before vacation in January, and keep muscle. I’m on enough juice to not lose in a deficit and I’m doing a PPL approximately 5-6 times pr week. I’m around 10-12% BF now, the leanest I have ever been.

Open for suggestions.

Macros:

250-300g protein
50-80g fat
Varying carbs from day to day, but 250-450g
Click to expand...
Same issue, I'm at 15mg reta.

But also 7mg a week is nothing, you can easily go upto 12 or even 15mg.

Cagri will work btw, I basically get 0 supression from most drugs, I just don't respond as well.

With Cagri I got skeptical, I am rly skeptical and distrusting person when it comes to the effectiveness of drugs. But after titrating doses, it works, Very Well in fact after u reach the perfect dose.

I have never felt this full in my life since I first started blasting reta.

I'll def try to abuse it until it's useless. As I continue to bulk I'll probably be able to not titrate it any further.
 
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