Loving my first go at tesamorelin

[Ateam2023]

its a futile attempt the further i search , but it was a hopeful idea, but @5 ius of hgh daily i doubt any amount of tesa would make an impact, may make it worse,,

 

[bubba618]

I havent used Ipamorelin however i habe used a other GHRP: GHRP-2 in combination with the GHRH CJC-1295 NO dac. Im thinking about switching tge CJC with Tesa and see if i will get better results

Just bear in mind that CJC-1295 and tesamorelin are both GHRHs and act on the same receptors which could lead to receptor saturation and desensitization.

If you are trying to maximize your ROI with GHS peptides, pair a GHRH with a GHRP as the act on different pathways to increase endogenous GH production and release.

Hexarelin will help give you the greatest endogenous GH spike but can increase cortisol and prolactin levels whereas ipamorelin has a more moderate effect on GH but does not impact cortisol or prolactin. Neither have a strong effect on hunger unlike their predecessors. So hexarelin and ipamorelin would be the two GHRHs I would consider for synergistic pairing with a goal of maximizing endogenous GH secretion.

Remember, your body has limits on how much GH it can produce and release as a biological limit which is why a lot of people move past secretagogues to exogenous GH. Using two or more compounds which act on different pathways is a way to maximize desired outcomes while minimizing negative side effects. Tesamorelin is already the strongest GH secretagogue, so you want to pair it with something that will work via different pathways to signal production and release of endogenous GH.

The article from LimitlessLifeNootropics compares tesamorelin to ipamorelin as monotherapies meant to increase endogenous GH to similar levels. This would mean having to run ipamorelin doses at many times the tesamorelin dose to achieve similar levels and yes, at those levels ipamorelin will be stimulating the ghrelin receptors massively triggering both hunger and fat storage.

But the goal is not to use ipamorelin (or hexamorelin for that matter) to replace tesamorelin, but to add to its endogenous GH production/release. At that point the question is which meets your goals? For long-term use with minimal sides, choose ipamorelin. For a short-term, blast-style run choose hexarelin.

 

[Ghoul]

its a futile attempt the further i search , but it was a hopeful idea, but @5 ius daily i doubt any amount of tesa would make an impact, may make it worse,,

Tesa is not a particularly pleasant injection in my experience. Frequent site reactions. Nothing terrible, but not worth doing if it's going to be futile.

 

[Nidus]

Just bear in mind that CJC-1295 and tesamorelin are both GHRHs and act on the same receptors which could lead to receptor saturation and desensitization.

If you are trying to maximize your ROI with GHS peptides, pair a GHRH with a GHRP as the act on different pathways to increase endogenous GH production and release.

Hexarelin will help give you the greatest endogenous GH spike but can increase cortisol and prolactin levels whereas ipamorelin has a more moderate effect on GH but does not impact cortisol or prolactin. Neither have a strong effect on hunger unlike their predecessors. So hexarelin and ipamorelin would be the two GHRHs I would consider for synergistic pairing with a goal of maximizing endogenous GH secretion.

Remember, your body has limits on how much GH it can produce and release as a biological limit which is why a lot of people move past secretagogues to exogenous GH. Using two or more compounds which act on different pathways is a way to maximize desired outcomes while minimizing negative side effects. Tesamorelin is already the strongest GH secretagogue, so you want to pair it with something that will work via different pathways to signal production and release of endogenous GH.

The article from LimitlessLifeNootropics compares tesamorelin to ipamorelin as monotherapies meant to increase endogenous GH to similar levels. This would mean having to run ipamorelin doses at many times the tesamorelin dose to achieve similar levels and yes, at those levels ipamorelin will be stimulating the ghrelin receptors massively triggering both hunger and fat storage.

But the goal is not to use ipamorelin (or hexamorelin for that matter) to replace tesamorelin, but to add to its endogenous GH production/release. At that point the question is which meets your goals? For long-term use with minimal sides, choose ipamorelin. For a short-term, blast-style run choose hexarelin.

Ipamorelin did raise Prolactin for me greatly. Tried 4 different brands and always had a huge spike in prolactin although sleep on ipa was amazing

 

[bubba618]

Anything beyond 2iu rHGH shuts down endogenous GH pulses, and Tesa only amplifies what's being naturally produced.

Elevated IGF from rHGH causes somatostatin to be released, which binds to and shuts down somatotrophs, the GH producing cells in the pituitary, so there's nothing to amplify. Tesa (Growth Hormone Releasing Hormone) is sending a signal to increase GH, but the receivers are shut off.

Part of the reason to pair with ipamorelin or another GHRP is that GHRPs suppress somatastatin thus amplifying the overall endogenous GH response.

 

[bubba618]

Ipamorelin did raise Prolactin for me greatly. Tried 4 different brands and always had a huge spike in prolactin although sleep on ipa was amazing

Part of ipamorelin's design was to not raise cortisol or prolactin which is a problem with other GHRPs, but there are always some people who like yourself it wasn't as effective for.

I appreciate the feedback as I haven't seen too many people talk about having raised prolactin due to ipamorelin. Thanks!

 

[Photon]

SSA is running a Tesa promo next month which I'm planning to get a 6 months supply of. What's a good GHRP to run alongside it for burning visceral fat? I see people mentioning IPA more often vs Hex.

IPA 2mg with Tesa 2mg? Pinned before sleep (for improving sleep quality?)
P5P for prolactin control? Do we need this tho?

Linking this for those interested..

B

Thread 'Hexarelin vs ipamorelin vs tesamorelin...'

Feb 15, 2025

Currently using Hex since it jas shown benefits for the heart. Starting comparing to ipamorelin and tesamorelin and I like ipa, so considering changing. Any thoughts? Fat burn isnt a concern so looking at other benefits. Currently on hgh 3iu daily

• Bigoldguy
• Replies: 53
• Forum: Human Growth Hormone and Peptides

 

[Vicki]

I used GH, then Tesa for a year, That's what Tesa is optimized for. Punching through visceral fat that's become resistant to hormone signaling so it doesn't release its fat. This happens with age, the longer visceral fat sits there the less responsive it becomes, and eventually fibrosis develops making it rock hard. It's also really bad for your health. Much more dangerous than subcutaneous.

The FDA indication for Tesa is specifically to counteract the psychological distress otherwise fit men experience from using anti-HIV drugs that cause rapid growth of visceral fat deposits. Otherwise lean guys with big guts.

Even though it boosts IGF like GH, the visceral fat reduction is Tesa's main effect, and the other GH like effects, better skin, nails, etc, are present but less pronounced and slower to come on than GH,

GH also reduces stubborn visceral fat, but takes large doses (and sides) to get the same rapid effect as Tesa.

Something about Tesa keeping natural pulsatile GH release that makes it so good at visceral fat annihilation. Tesa itself doesn't cause lose weight, the visceral fat just gets redistributed to areas it's
easier to lose with diet and exercise,

Since sides are minimal with Tesa, it's very safe, and timing of the dose is irrelevant (it just amplifies your natural GH release keeping the GH axis intact), it's a good starter for 35+ year olds. 6 months daily injections will almost effortlessly recomp a hardened gut, improve skin and hair, then transition to GH to maintain the visceral fat loss and expand benefits to other areas.

Funny thing is those visceral fat inducing anti-HIV drugs aren't really even used any more, but the pharmaceutical company keeps coming out with new, more concentrated (for easier injections)versions of Tesa (Egrifta). I suspect a lot of people are getting this prescribed off label, since it's illegal to prescribe rHGH for anything other than short children and adults with GH deficiency or muscle wasting.

Combined with Tirz or Reta, and TRT it's the most potent visceral fat reduction stack there is.

https://www.theratech.com/news-releases/news-release-details/theratechnologies-receives-fda-approval-egrifta-wrtm-tesamorelin

Is there any info on what theyre doing to make it more potent? Are they actually changing the peptide at all or is the excipient formula helping it have a longer half life?

I'm wondering if the common raw source on the market is the same as whatever the current version of egrifa would be. Should people be dosing chinese tesa as if it were egrifta version 1 or this latest version 3?

 

[Nidus]

Part of ipamorelin's design was to not raise cortisol or prolactin which is a problem with other GHRPs, but there are always some people who like yourself it wasn't as effective for.

I appreciate the feedback as I haven't seen too many people talk about having raised prolactin due to ipamorelin. Thanks!

My prolactin went crazy, after 3 weeks at 300mcg every evening it was at 68!
Almost turned into a human cow!

 

[Ghoul]

Is there any info on what theyre doing to make it more potent? Are they actually changing the peptide at all or is the excipient formula helping it have a longer half life?

I'm wondering if the common raw source on the market is the same as whatever the current version of egrifa would be. Should people be dosing chinese tesa as if it were egrifta version 1 or this latest version 3?

Tesamorelin, like rHGH tends to aggregate. Once that happens, the proteins in that aggregate aren't biologically active.

The latest formulation added cyclodextrin to the excipients. Cyclodextrin is so effective at preventing aggregation, 1.28mg is as effective as 2mg was with the previous formulation because you're not losing 35% of the peptide to aggregation any more.

It's so effective you can leave it at room temp for a week after reconstitution.

(Doesn't everyone read Cyclodextrin News? lol)

Cyclodextrin News

Cyclodextrin-based super-generics represent enhanced versions of reformulated drug products, offering improved performance and patient outcomes usually developed/marketed by a generic company. Here…

cyclodextrinnews.com

From the patent:

"“The inclusion of hydroxypropyl-β-cyclodextrin in the lyophilized matrix prevents aggregation of the tesamorelin peptide during reconstitution and storage."

(and yes, it works for rHGH too, but no one's released a commercial product using it yet afaik)

 

[Photon]

Tesamorelin, like rHGH tends to aggregate. Once that happens, the proteins in that aggregate aren't biologically active.

The latest formulation added cyclodextrin to the excipients. Cyclodextrin is so effective at preventing aggregation, 1.28mg is as effective as 2mg was with the previous formulation because you're not losing 35% of the peptide to aggregation any more.

It's so effective you can leave it at room temp for a week after reconstitution.

(Doesn't everyone read Cyclodextrin News? lol)

Cyclodextrin News

Cyclodextrin-based super-generics represent enhanced versions of reformulated drug products, offering improved performance and patient outcomes usually developed/marketed by a generic company. Here…

cyclodextrinnews.com

From the patent:

"“The inclusion of hydroxypropyl-β-cyclodextrin in the lyophilized matrix prevents aggregation of the tesamorelin peptide during reconstitution and storage."

Almost 100% sure no UGL will have this in any peptide..

 

[Ghoul]

Almost 100% sure no UGL will have this in any peptide..

I'm sure they don't, but at $20/kg it would be nice if a Chinese peptide chemist started using it as an excipient.

 

[Photon]

I'm sure they don't, but at $20/kg it would be nice if a Chinese peptide chemist started using it as an excipient.

View attachment 336655

Would this work if i just add this to my BAc water?

 

[Ghoul]

Would this work if i just add this to my BAc water?

Here's the formula for a 7 dose vial

Amount per vial reconstituted with 1.3ml bacteriostatic water:

Amount per Daily Dose (~0.16 mL)

Tesamorelin (active) 11.6 mg

Hydroxypropyl‑β‑cyclodextrin 145 mg

Mannitol 43.5 mg

 

[Wizbang]

SSA is running a Tesa promo next month which I'm planning to get a 6 months supply of. What's a good GHRP to run alongside it for burning visceral fat? I see people mentioning IPA more often vs Hex.

IPA 2mg with Tesa 2mg? Pinned before sleep (for improving sleep quality?)
P5P for prolactin control? Do we need this tho?

Linking this for those interested..

B

Thread 'Hexarelin vs ipamorelin vs tesamorelin...'

Feb 15, 2025

Currently using Hex since it jas shown benefits for the heart. Starting comparing to ipamorelin and tesamorelin and I like ipa, so considering changing. Any thoughts? Fat burn isnt a concern so looking at other benefits. Currently on hgh 3iu daily

• Bigoldguy
• Replies: 53
• Forum: Human Growth Hormone and Peptides

a promo ?! tell me more haha

 

[Photon]

Here's the formula for a 7 dose vial

Amount per vial reconstituted with 1.3ml bacteriostatic water:

Amount per Daily Dose (~0.16 mL)

Tesamorelin (active) 11.6 mg

Hydroxypropyl‑β‑cyclodextrin 145 mg

Mannitol 43.5 mg

Thats almost 1.2g of cyclodextrin in 1.3ml lol

a promo ?! tell me more haha

Probably just a price drop + free ship.

 

[Ghoul]

Thats almost 1.2g of cyclodextrin in 1.3ml lol



Probably just a price drop + free ship.

That's a typo and too late to edit.

Those are quantities per 1.3ml, the entire vial, so divide by 7 for per dose amounts.

Also, there are 20+ types of cyclodextrin, Hydroxypropyl‑β‑cyclodextrin is the only form the FDA found to be non-toxic for injections, even high dose IV drips.

 

[keenpen]

Is there a general consensus on split dosing vs once at night before bed with tesa?

What about the idea that glp1 slows gastric emptying and the best time to dose is first thing in the morning?

 

[Proud Pangolin]

with all the great talk about GLP's I wasnt considering reta a "risk" compound. I know its not FDA approved like Tirz, but was still considering it "safe".

Well "risk" compound is relativ as always with such things. However just to give you the list of only the brain areas that Reta affects:

Arcuate Nucleus (ARC), Paraventricular Nucleus (PVN), Ventromedial Hypothalamus (VMH), Lateral Hypothalamic Area (LHA), Dorsomedial Hypothalamus (DMH), Nucleus Tractus Solitarius (NTS), Area Postrema (AP), Parabrachial Nucleus (PBN), Amygdala, Hippocampus, Ventral Tegmental Area (VTA), Nucleus Accumbens (NAc).

Our body is a highly complex system. I simply hold the opinion that its not a good idea to careless throw something in, that affects so many pathways. Not to speak about the effects we dont know of.

At the same time Berberine wont do this or at least not nearly to this extend. So go with that.

Doenst mean that Tirz is a dnagerous compound but just because its FDA approved doesnt mean its safe. We know nothing about long term risks. And this goes especially for people who already take multiple compounds.

Like seriously there are enough guys who are on: test, primo,tren (or any other 19-nors that fucks with their dopamine,prolactine etc), of course HGH, Reta to deal with insulin from HGH and for fatloss, Cardarine to combat the endurance reduction from tren, an aromatase inhibitor, finasterid to block DHT aswell as RU so they keep their hair, Methyleneblue because why not, some peptides for better sleep....

You can go on, you get the idea. I always choose the "least amount possible" to deal with an issue

 

[Proud Pangolin]

Just bear in mind that CJC-1295 and tesamorelin are both GHRHs and act on the same receptors which could lead to receptor saturation and desensitization.

If you are trying to maximize your ROI with GHS peptides, pair a GHRH with a GHRP as the act on different pathways to increase endogenous GH production and release.

Hexarelin will help give you the greatest endogenous GH spike but can increase cortisol and prolactin levels whereas ipamorelin has a more moderate effect on GH but does not impact cortisol or prolactin. Neither have a strong effect on hunger unlike their predecessors. So hexarelin and ipamorelin would be the two GHRHs I would consider for synergistic pairing with a goal of maximizing endogenous GH secretion.

Remember, your body has limits on how much GH it can produce and release as a biological limit which is why a lot of people move past secretagogues to exogenous GH. Using two or more compounds which act on different pathways is a way to maximize desired outcomes while minimizing negative side effects. Tesamorelin is already the strongest GH secretagogue, so you want to pair it with something that will work via different pathways to signal production and release of endogenous GH.

The article from LimitlessLifeNootropics compares tesamorelin to ipamorelin as monotherapies meant to increase endogenous GH to similar levels. This would mean having to run ipamorelin doses at many times the tesamorelin dose to achieve similar levels and yes, at those levels ipamorelin will be stimulating the ghrelin receptors massively triggering both hunger and fat storage.

But the goal is not to use ipamorelin (or hexamorelin for that matter) to replace tesamorelin, but to add to its endogenous GH production/release. At that point the question is which meets your goals? For long-term use with minimal sides, choose ipamorelin. For a short-term, blast-style run choose hexarelin.

You understood me wrong. Im currently taking CJC no dac + GHRP-2. And i want to switch CJC with another GHRH-> Tesamorelin.

The GHRP-2 im.primarly taking to inhibit the Soma.

I also thought of switching GHRP-2 with Ipamorelin as im getting somewhat of a cortisol reaction from it (starting to get a rash in my face after like 4 weeks and im guessing this is due to cortisol)