Hgh vial fell down, throw away or still good?

[LeeroyMatinta]

I had a hgh vial fell down, after the fall it formed bubbles. Is it still good as long as I wait for the bubbles to go away or should I throw it away?

Its my last vial and new stock comes in about 1-2 weeks. But i was at a build up so was doing only 2 iu (had too many sides previously on 8iu) so not a big deal if the usual is to throw it away.

 

[Ghoul]

Drops have been 100% proven to damage rHGH.

Temps inside cavitation bubbles in dropped rHGH solutions can reach 10,000° C, so damage isn't surprising.

If you have a syringe filter. you can remove
the particles of most concern that this damage creates, large aggregates.

The other type of damage is oxidation to rHGH monomers, but those end up strongly sticking to the vial wall so you won't be injecting much, if any of those.

If you can filter it, it's not going to be any riskier than any other UGL gh.

If you can't filter it, and you don't really need that last vial, despite the overall risk being relatively small, you'd be better off not using it.

 

[Ateam2023]

I had a hgh vial fell down, after the fall it formed bubbles. Is it still good as long as I wait for the bubbles to go away or should I throw it away?

Its my last vial and new stock comes in about 1-2 weeks. But i was at a build up so was doing only 2 iu (had too many sides previously on 8iu) so not a big deal if the usual is to throw it away.

dude you start the most ridiculous threads, Are you seriously that dense? throw it away, or use it who cares its one vial,,

 

[AlexDavis43]

I had a hgh vial fell down, after the fall it formed bubbles. Is it still good as long as I wait for the bubbles to go away or should I throw it away?

Its my last vial and new stock comes in about 1-2 weeks. But i was at a build up so was doing only 2 iu (had too many sides previously on 8iu) so not a big deal if the usual is to throw it away.

dude you start the most ridiculous threads, Are you seriously that dense? throw it away, or use it who cares its one vial,,

Agree, use it or don't. No big deal. It's just one vial, not a game changer either way.

GH is a long-game; just don't make a habit of playing soccer with vials of reconstituted GH xD

 

[Ghoul]

One of a half dozen carefully conducted, peer reviewed journal published studies that demonstrate drops of even a few inches damages rHGH in a way that presents risks to health.

Polysorbate is added to many liquid formulations of rHGH specifically to prevent this from happening. Are we going to once again assume "big pharma" is just stupid, tossing in unnecessary ingredients to guard against non-existent risks?

DO NOT DROP: MECHANICAL SHOCK IN VIALS CAUSES CAVITATION, PROTEIN AGGREGATION AND PARTICLE FORMATION - PMC

Industry experience suggests that g-forces sustained when vials containing protein formulations are accidentally dropped can cause aggregation and particle formation. To study this phenomenon, a shock tower was used to apply controlled g-forces to ...

pmc.ncbi.nlm.nih.gov

Why shame someone for asking a reasonable question. It's like some people just don't want to hear things that go against their assumptions that "it's all good".

I mean if it doesn't interest you, you're not curious, fair enough, but no one's forcing it on anyone.

 

[BigDadd7]

Very o

One of a half dozen carefully conducted, peer reviewed journal published studies that demonstrate drops of even a few inches damages rHGH in a way that presents risks to health.

Polysorbate is added to many liquid formulations of rHGH specifically to prevent this from happening. Are we going to once again assume "big pharma" is just stupid, tossing in unnecessary ingredients to guard against non-existent risks?

DO NOT DROP: MECHANICAL SHOCK IN VIALS CAUSES CAVITATION, PROTEIN AGGREGATION AND PARTICLE FORMATION - PMC

Industry experience suggests that g-forces sustained when vials containing protein formulations are accidentally dropped can cause aggregation and particle formation. To study this phenomenon, a shock tower was used to apply controlled g-forces to ...

pmc.ncbi.nlm.nih.gov

Why shame someone for asking a reasonable question. It's like some people just don't want to hear things that go against their assumptions that "it's all good".

I mean if it doesn't interest you, you're not curious, fair enough, but no one's forcing it on anyone.

Very interesting. I would have never guessed that.

 

[Ateam2023]

where's your post @readalot ?. that was funny

 

[Ghoul]

Very o

Very interesting. I would have never guessed that.

Info like this is useful in developing best practices, like sanitizing stopper tops, for anyone interested in finding the ideal way to do things, which usually consists of small details.

So now I take a little extra care to avoid tapping reconstituted peptide vials on hard surfaces. I handle them on a mat instead of a marble counter.

Is either a huge deal? I could probably never sanitize another vial top and it won't kill me. Is the cumulative impact of treating reconstituted vials gently meaningful? Over the course of using hundreds of vials and thousands of injections. Maybe. Why not?

 

[readalot]

where's your post @readalot ?. that was funny

Probably too much. Sorry.

 

[Ghoul]

Cavitation from impact in real time.

Instantly, within each tiny bubble, hundreds of thousands of rHGH monomers unfold, ruined, and stick to each other to permanently form into a single large aggregated particle, while others get "fried" via oxidation and stick to the vial walls like glue.

https://jpharmsci.org/cms/10.1002/jps.24259/attachment/05f96ebb-0fe6-4c4c-b7b8-212dbff60459/mmc6.mp4

 

[juicebro]

So the same should apply for squirting water on top of it when reconstituting because that too forms bubbles?

 

[TurboJet]

 

[Ghoul]

So the same should apply for squirting water on top of it when reconstituting because that too forms bubbles?

Yes.

It's not the same as cavitation damage, but bubbles and foam degrade rHGH. Not from the intense heat and pressure of shock induced cavitation, but from the "Air / Water Interface".

Any commercial rHGH with Polysorbate or Polaxamer, which is most of them, is including that ingredient to prevent that type of degradation from happening. Or they're all idiots and imagining things...




Just minimize bubbles and foam as much as you can. If it happens don't lose any sleep over it and try a different technique next time.

 

[Benf15harp]

If that tough sob got back up I’d say there’s still some life in that little fella and will probably give you the best hormonal growth it can while you wait for resupply. Lol.

 

[Eddie.]

dude you start the most ridiculous threads, Are you seriously that dense? throw it away, or use it who cares its one vial,,