Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[chmuse]

This is always my first thought with any pharma product that made it passed costly initial development. and was canned when testing started.

80% of peptide drugs fail at a late stage, sometimes as late as the first human injection.

People don't realize the intense scrutiny these protein drugs must be put under.

"In silico" testing, where the predict every potential thing that can go wrong, degradation, aggregation, manufacturing by products, and each of those proteins is checked to estimate its potential harm,

If one thing changes, 1 degree of temperature in the manufacturing room, a different stopper material in the vial, it's got to be checked again for potentially new proteins that can form.

AAS are like bricks, these are microchips by comparison.

One of the current dramas in the peptide world is how a seller got their hands on this peptide everyone wanted, but no one else was willing to sell. Turns out it's because it degrades so terribly in transportation, and anyone who'd done any amount of research should have realized this. Instead everyone is out money and everyone's pissed about it.

Sometimes there's no researching happening at all, just "this person I see posting a lot says it's great, so now I want to try it!"

 

[Ghoul]

One of the current dramas in the peptide world is how a seller got their hands on this peptide everyone wanted, but no one else was willing to sell. Turns out it's because it degrades so terribly in transportation, and anyone who'd done any amount of research should have realized this. Instead everyone is out money and everyone's pissed about it.

Sometimes there's no researching happening at all, just "this person I see posting a lot says it's great, so now I want to try it!"

100%.

Every time I hear "fillers" (it's "excipient ingredients" and their presence or. lack thereof is nearly as important as the peptide) reminds me how little folks understand about all the things that matter besides a "purity" test, and that the other "impurity" 1-5% of stuff in that vial isn't wholesome flakes of angel dandruff.

Look up "peptide impurity characterization" and "peptide mapping" to get a handle on just how blind we are to what's being injected.

If I said: "Inject this, it's 99% the drug you need, and 1% a mix of millions of random drug molecules, that most of the time do nothing noticeable, but we don't really know what effect they'll have", who would go for that deal?

That's the major difference with pharma peptides. They know what the impurities are, and have to confirm they're harmless to the FDA. We get peptides with completely unknown, unexamined impurities.

I say this as someone who engages in this risk taking as well, but I try to minimize it where I can.

 

[chmuse]

100%.

Every time I hear "fillers" (it's "excipient ingredients" and their presence or. lack thereof is nearly as important as the peptide) reminds me how little folks understand about all the things that matter besides a "purity" test, and that the other "impurity" 1-5% of stuff in that vial isn't wholesome flakes of angel dandruff.

Look up "peptide impurity characterization" and "peptide mapping" to get a handle on just how blind we are to what's being injected.

If I said: "Inject this, it's 99% the drug you need, and 1% a mix of millions of random drug molecules, that most of the time do nothing noticeable, but we don't really know what effect they'll have", who would go for that deal?

I say this as someone who engages in this risk taking as well, but I try to minimize it where I can.

I think you'd be surprised, plenty of people would take that deal to lose weight. I mean, people used to swallow tapeworm eggs. Humans can be very short sighted. (I am not excluding myself from that group.)

A couple of the testers (Jano, PT) have tried explaining that the purity percentage they provide is more of a feel-good thing, but people don't like hearing it.

 

[Ghoul]

I think you'd be surprised, plenty of people would take that deal to lose weight. I mean, people used to swallow tapeworm eggs. Humans can be very short sighted. (I am not excluding myself from that group.)

A couple of the testers (Jano, PT) have tried explaining that the purity percentage they provide is more of a feel-good thing, but people don't like hearing it.

Sure, evolution has given us excellent defenses against eating or inhaling harmful substances, contaminants landing in open wounds. but injecting bypasses those defenses (mostly).

Ahh well, if I didn't believe the benefit outweighed the risk I wouldn't be using these things. Still, safety should improve over time as long as we're educated and demand a better product.

I'd love to seen Peptide suppliers get a handle on PH. That's so easy with the right excipients, and can slow degradation to a crawl.

 

[glpfun]

lol wtf

 

[malleolus]

And yeah, there kits of most oils were pretty awesome too. Not the best quality gears but good enough. Especially considering price.

Not the best Quality? You forgot the last batch of oils they tested?

Since i was customer of QSC (Spring 2024) I had around 20 Kits of Oils and about 25 kits of GH, and a handful of other Peptid kits.

One Oil vial was broken and they sent me a replacement in the next order.
One vial of those 200 had visible floaters.

The price-quality ratio from them was the best.

 

[Ghoul]

View attachment 319311
lol wtf

Post in thread '*Another* MESO-Rx Ranking System'

Mar 2, 2025

Hey look, I finally figured out how to hack the ranking system!

• Ghoul

• 
• 
• 

 

[chmuse]

Sure, evolution has given us excellent defenses against eating or inhaling harmful substances, contaminants landing in open wounds. but injecting bypasses those defenses (mostly).

Ahh well, if I didn't believe the benefit outweighed the risk I wouldn't be using these things. Still, safety should improve over time as long as we're educated and demand a better product.

I'd love to seen Peptide suppliers get a handle on PH. That's so easy with the right excipients, and can slow degradation to a crawl.

I wasn't disagreeing with you- I was saying people are okay with doing dumb things that put their health at risk to lose weight. Not that these things aren't unhealthy. For some people taking them- you've got people who started at 450+ lbs- they're likely healthier having taken them, even with all the risks, than not having taken them.

That being said, it's two very different audiences using the same medication. Someone here probably has a very different risk/reward ratio than most people using them.

 

[NiMa]

from January 10th to February 12th it was 70%. Accordingly, 100% would be reached on February 26th. He's already been over it for 4 days.

 

[glpfun]

Post in thread '*Another* MESO-Rx Ranking System'

Mar 2, 2025

Hey look, I finally figured out how to hack the ranking system!

• Ghoul

• 
• 
• 

I don’t get it

 

[Ghoul]

I don’t get it

You're better off. Stay right here in this thread where it's peaceful.

 

[malleolus]

from January 10th to February 12th it was 70%. Accordingly, 100% would be reached on February 26th. He's already been over it for 4 days.

You know that it may be that the last 30% can be harder to achieve and need same amount of time like the first 70% or even longer..?

 

[mok4315]

I don’t get it

The ranking system has officially been retired today as a follow-up to our original announcement on February 18, 2025.

No more ranks!

 

[NiMa]

You know that it may be that the last 30% can be harder to achieve and need same amount of time like the first 70% or even longer..?

It was a fun theory and not meant seriously

 

[piggy_nui]

I wasn't disagreeing with you- I was saying people are okay with doing dumb things that put their health at risk to lose weight. Not that these things aren't unhealthy. For some people taking them- you've got people who started at 450+ lbs- they're likely healthier having taken them, even with all the risks, than not having taken them.

That being said, it's two very different audiences using the same medication. Someone here probably has a very different risk/reward ratio than most people using them.

Amazing how people will do anything to lose weight except eating healthy and doing exercises. Anything to lose weight and keep stuffing their faces with fast food.

 

[glpfun]

If there isn’t a ranking system I have no incentive to behave now. Colored name was the only thing holding me back. I’m gonna unleash the beast.

 

[chmuse]

Amazing how people will do anything to lose weight except eating healthy and doing exercises. Anything to lose weight and keep stuffing their faces with fast food.

Amazing how someone can have such strong opinions while being so uninformed. Par for the course, I suppose; it's easier to think 30-40% of the population is lazy and gluttonous than to consider something may be wrong.

 

[glpfun]

Amazing how people will do anything to lose weight except eating healthy and doing exercises. Anything to lose weight and keep stuffing their faces with fast food.

I struggled with weight loss and being consistent with anything in life until I got on tirz and test. Literally transformed my entire life in half a year. I lift 3 days on 1 off repeat consistently, I do more cardio now, and I count my calories and generally do much better with high protein low fat diets, but still room for improvement. I tried so many times before and it never stuck more than a couple weeks and then when I get on tirz and test it magically changed. My progression around nutrition with tirz was initially leaning into appetite suppression but being lethargic from deficit so began counting calories and being intentional with macros and lethargy disappeared and my relationship with food started changing. I’m not entirely sure what your point was, but just pointing out that for many well intentioned people they just needed a little push or a little bit extra. This seems in line with genetic variations in other areas doesn’t it? Some people probably struggle with things like food noise or focus more than others for reasons mostly out of their control.

 

[Proud_papa_pump]

Amazing how people will do anything to lose weight except eating healthy and doing exercises. Anything to lose weight and keep stuffing their faces with fast food.

This you?

 

[Thequadfather]

Amazing how people will do anything to lose weight except eating healthy and doing exercises. Anything to lose weight and keep stuffing their faces with fast food.

For many people struggling with obesity. Their challenges with controlling caloric intake stem for mental health challenges. A lot of people eat to cope with stress and anxiety. GLPs shut down that “food noise” in the brain that stems from the stress response. It’s not so simple as it appears to those of us who don’t have those struggles. It’s like telling someone with depression, “lol just go outside for some sunshine you’ll feel happy”.