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Ghoul said:
Aggregates form when the peptide is in liquid form during manufacturing or after reconstitution.

After filtration, the peptide solution will be free of large aggregates. However, depending on the specific peptide, PH of the solution, concentration, and other factors, aggregates can reform. (ie 1 point of PH difference can speed up aggregate formation 10x in HGH).

So filtering as close to administration is ideal, since there's no "incubation" time for new aggregates to form.

Tesa is compound known to induce site reactions even in pharma formulations. After filtering into a new vial there was no site reaction during the first dose vs the painful unfiltered Tesa.

However, by the 3rd, 4th, and 5th daily doses pain gradually intensified, suggesting aggregates reformed.

By filtering each dose just before use, those injection site reactions are virtually eliminated, which suggests a lower level of immunogenicity, to maintain maximum efficacy.

Not every peptide is as prone to rapid aggregation so filtering into a vial may be fine. But we usually don't even know whether the PH of a peptide solution is correct. I just per dose filter them all now. I could do it blindfolded.

That said, I'm not wagging my finger at anyone saying you must do this. I've decided this is a low effort process I'm willing to use because of what my research into aggregation has shown me the benefits likely are.

Here's a little about "incubation" in a wonky paper about GLP aggregation I was reading earlier today.

View attachment 317276View attachment 317277

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I spoke to a diff vendor who said they filter the product before lyophilization. Does this count as enough filtering prior to use?
 
Anyone follow Dr William Seeds? He wrote Peptide Protocols and has a podcast. I listened to a few episodes last year, but I need to listen to more to get a better idea of him.

Maybe someone more familiar with his material can chime in. I looked through a few specific sections of the Peptide ebook and it mostly matched with protocols I've read about.

seeds.md

Dr. William Seeds | Seeds.md

This is the homepage for William A. Seeds MD, Board Certified Orthopedic Surgeon, Residency Site Director for University Hospital in Geneva and Conneaut OH, and the Founder of the Seeds Scientific Research and Performance (SSRP) Institute, a medical education and certification program for...
seeds.md seeds.md
 
Trailmixed said:
I spoke to a diff vendor who said they filter the product before lyophilization. Does this count as enough filtering prior to use?
Click to expand...
Filtering raws before lypholisation is standard practice (at least it should be).

I would suspect the sources who provide vials that aren't either nitrogen or vacuum sealed, have possibly skipped the filtering process.

The raws are reconstituted, then injected/filtered into vials, then lypholised and sealed.

The source has simply put raws into a vial and skipped the filtering, lypholisation + vacuum seal / nitrogen seal process.

I say this because those providing unfiltered peptides probably aren't going to have lypholisation and sealing capabilities. It's not a huge process to reconstitute and filter prior to lypholisation
 
Bizzark1 said:
Filtering raws before lypholisation is standard practice (at least it should be).

I would suspect the sources who provide vials that aren't either nitrogen or vacuum sealed, have possibly skipped the filtering process.

The raws are reconstituted, then injected/filtered into vials, then lypholised and sealed.

The source has simply put raws into a vial and skipped the filtering, lypholisation + vacuum seal / nitrogen seal process.

I say this because those providing unfiltered peptides probably aren't going to have lypholisation and sealing capabilities. It's not a huge process to reconstitute and filter prior to lypholisation
Click to expand...
So this source I am alluding to is presumably doing that process of reconstituting the raws then filtering it into a sterile vial vacuum sealed then lyophilizing them?
 
Dirthand said:
Well I talk about tid bits because it's part of my story and in turned going there saved my life and entailed me to change into the great person I am and love today.... so no I do not mind talking about it to an extent.... the where and why isn't important because that's not who u am anymore... so not not rally but some thing for.my anonymity is better kept private.. there arr definitely a person here that knows my WHOLE story and she knows who her fine ass is.. lol obviously she got to know me and and ask. She is solid as they come.. anyone is welcome to do the same and eventu with trust I hold nothing back... you my girl M.....
Peace
D
Click to expand...
We all have a past. Some of us had a tough one and with plenty of mistakes/bad choices.

Is not our past that define you, especially if you used who you were to become the better man you are today.

I am happy for you brother. Be better man and let the loved ones reap the benefits of this better you.

Stay strong, who you were is there to remind you who you don't want to be anymore and how far you came.
 
bubba618 said:
None of those are peptides. GABA is a neurotransmitter, melatonin is a hormone, and histidine, taurine and theanine are amino acids or amino acid derivatives. The histidine, taurine, theanine and melatonin are all orally bioavailable and GAGA can be made more bioavailable orally in liposomal form. You're probably better off taking these orally.

Peptides for sleep would be epitalon and/or DSIP. Other peptides which might help sleep quality are selank and semax.

I've used all four of these peptides and epitalon seemed to have the most profound effect on my sleep running 10mg nightly for 2 weeks twice per year. I know some people microdose it year-round, but I can't speak to how effective that is.
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Yea. I misspoke. I bought it premixed from a Domestic peptide source. I take Taurine, GABA and melatonin daily already in supplement form. Most of those peptides for sleep you listed don’t work very well and are a waste of time and money.
 
Trailmixed said:
So this source I am alluding to is presumably doing that process of reconstituting the raws then filtering it into a sterile vial vacuum sealed then lyophilizing them?
Click to expand...
Yeah I'd say so, usually only the sloppiest local labs are scooping raws into vials and crimping + it's not much more expensive to import finished peptides from china vs importing raws and messing around with vials, scales, crimping etc
 
Have someone tried Trest A from the old EU warehouse? I have some that I got early summer, one kit black caps one kit lightblue caps(dont know why the send me two different caps in one order, allthough they insist both are ment, as I thought they may have confused Trest with Test). Been doing the light blue caps for 3 weeks now, 25mg ED and It feels very underwhelming.

Anyone who ran the black or blue caps from eu warehouse recently and can share their experience?
 
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